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Gene Review

ompC  -  outer membrane porin protein C

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2207, JW2203, butR, meoA, par
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Disease relevance of ompC

  • A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene [1].
  • This was accomplished by employing a genetic scheme in which two simultaneous selections enriched for ompC mutants defective in phage attachment, but retained functional channels [2].
  • On the other hand, transformants carrying a plasmid encoding the Salmonella typhi ompC gene remained as resistant to the drug as the parental strain, even though they overexpressed OmpC [3].
  • The csaA, -B, -C, -E operon was cloned on a stabilized plasmid downstream from an osomotically regulated ompC promoter. pGA2-CS4 directs production of CS4 fimbriae in both E. coli DH5alpha and Shigella flexneri 2a vaccine strain CVD 1204, as detected by Western blot analysis and bacterial agglutination with anti-CS4 immune sera [4].

High impact information on ompC

  • To study the structure-function relationship of these proteins, we have constructed a series of ompC-phoE hybrid genes in which the DNA encoding part of one protein is replaced by the corresponding part of the other gene [5].
  • DNase I protection studies showed that ChxR bound to sites in the ompF and ompC promoter proximal regions that overlap but were distinct from OmpR binding sites [6].
  • Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli [7].
  • We used the property that small RNAs are often involved in RNA-RNA interactions to capture RseX putative partners; ompA and ompC mRNA, which encode two major outer membrane proteins, were identified [8].
  • Two different sequence motifs were found to be protected by OmpR in both the ompF and ompC promoter regions [9].

Chemical compound and disease context of ompC


Biological context of ompC


Anatomical context of ompC


Associations of ompC with chemical compounds


Regulatory relationships of ompC


Other interactions of ompC

  • Antisera were raised against the purified Escherichia coli K12 outer membrane proteins ompA-, ompC- and ompF proteins and protein e [18].
  • Measurements with other salts indicated a drastic change in the ionic selectivity when the fusion site in the ompC-phoE hybrid genes passed along the sequence of the porins from the N-terminal to the C-terminal end [19].
  • Osmo-inducible fusions of phoA were found to ompC and to a gene that is probably proU [20].
  • In addition, we show that the expression of ompF under the lpp promoter has no direct effect on ompC expression [21].
  • The single rmf and rpoS, but not ompC, mutant only slightly reduced cell viability [22].

Analytical, diagnostic and therapeutic context of ompC


  1. A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene. Mizuno, T., Chou, M.Y., Inouye, M. J. Biol. Chem. (1983) [Pubmed]
  2. A genetic approach for analysing surface-exposed regions of the OmpC protein of Escherichia coli K-12. Vakharia, H., Misra, R. Mol. Microbiol. (1996) [Pubmed]
  3. Clinical isolate of a porinless Salmonella typhi resistant to high levels of chloramphenicol. Toro, C.S., Lobos, S.R., Calderón, I., Rodríguez, M., Mora, G.C. Antimicrob. Agents Chemother. (1990) [Pubmed]
  4. Genetic characterization and immunogenicity of coli surface antigen 4 from enterotoxigenic Escherichia coli when it is expressed in a Shigella live-vector strain. Altboum, Z., Levine, M.M., Galen, J.E., Barry, E.M. Infect. Immun. (2003) [Pubmed]
  5. Localization of functional domains in E. coli K-12 outer membrane porins. Tommassen, J., van der Ley, P., van Zeijl, M., Agterberg, M. EMBO J. (1985) [Pubmed]
  6. ChxR is a transcriptional activator in Chlamydia. Koo, I.C., Walthers, D., Hefty, P.S., Kenney, L.J., Stephens, R.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli. Forst, S., Delgado, J., Inouye, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Down-regulation of Porins by a Small RNA Bypasses the Essentiality of the Regulated Intramembrane Proteolysis Protease RseP in Escherichia coli. Douchin, V., Bohn, C., Bouloc, P. J. Biol. Chem. (2006) [Pubmed]
  9. Identification of the DNA-binding domain of the OmpR protein required for transcriptional activation of the ompF and ompC genes of Escherichia coli by in vivo DNA footprinting. Tsung, K., Brissette, R.E., Inouye, M. J. Biol. Chem. (1989) [Pubmed]
  10. Transfer of phosphoryl group between two regulatory proteins involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli. Aiba, H., Mizuno, T., Mizushima, S. J. Biol. Chem. (1989) [Pubmed]
  11. EnvZ-OmpR interaction and osmoregulation in Escherichia coli. Cai, S.J., Inouye, M. J. Biol. Chem. (2002) [Pubmed]
  12. Characterization by deletion and localized mutagenesis in vitro of the promoter region of the Escherichia coli ompC gene and importance of the upstream DNA domain in positive regulation by the OmpR protein. Mizuno, T., Mizushima, S. J. Bacteriol. (1986) [Pubmed]
  13. Suppression of a mutation in OmpR at the putative phosphorylation center by a mutant EnvZ protein in Escherichia coli. Brissette, R.E., Tsung, K.L., Inouye, M. J. Bacteriol. (1991) [Pubmed]
  14. The porin OmpC of Salmonella typhimurium mediates adherence to macrophages. Negm, R.S., Pistole, T.G. Can. J. Microbiol. (1999) [Pubmed]
  15. Genetically probing the regions of ribose-binding protein involved in permease interaction. Eym, Y., Park, Y., Park, C. Mol. Microbiol. (1996) [Pubmed]
  16. Transmembrane signaling. Mutational analysis of the cytoplasmic linker region of Taz1-1, a Tar-EnvZ chimeric receptor in Escherichia coli. Jin, T., Inouye, M. J. Mol. Biol. (1994) [Pubmed]
  17. Stereospecific positioning of the cis-acting sequence with respect to the canonical promoter is required for activation of the ompC gene by a positive regulator, OmpR, in Escherichia coli. Maeda, S., Ozawa, Y., Mizuno, T., Mizushima, S. J. Mol. Biol. (1988) [Pubmed]
  18. Antigenic relationships between pore proteins of Escherichia coli K12. Overbeeke, N., Van Scharrenburg, G., Lugtenberg, B. Eur. J. Biochem. (1980) [Pubmed]
  19. Molecular basis of porin selectivity: membrane experiments with OmpC-PhoE and OmpF-PhoE hybrid proteins of Escherichia coli K-12. Benz, R., Schmid, A., Van der Ley, P., Tommassen, J. Biochim. Biophys. Acta (1989) [Pubmed]
  20. The use of transposon TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically regulated genes in Escherichia coli. Gutierrez, C., Barondess, J., Manoil, C., Beckwith, J. J. Mol. Biol. (1987) [Pubmed]
  21. Uncoupling of osmoregulation of the Escherichia coli K-12 ompF gene from ompB-dependent transcription. Ramakrishnan, G., Ikenaka, K., Inouye, M. J. Bacteriol. (1985) [Pubmed]
  22. Decrease in cell viability in an RMF, sigma(38), and OmpC triple mutant of Escherichia coli. Samuel Raj, V., Füll, C., Yoshida, M., Sakata, K., Kashiwagi, K., Ishihama, A., Igarashi, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  23. Molecular characterisation of the Stc- mutation of Escherichia coli K-12. Misra, R., Reeves, P. Gene (1985) [Pubmed]
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