Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

flgL - flagellar hook-filament junction protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1068, JW1070, flaT

Fahrner, K.A. et al., Komeda, Y., Homma, M. et al., Ohnishi, K. et al.

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Disease relevance of flgL

The antibodies against HAP1 and HAP3 also specifically reacted with the gene products of flaS and flaT of Escherichia coli, respectively [1].

High impact information on flgL

The mutations mapped to the middle of flgL, to structural gene for HAP3, and sequence analysis revealed the same coding change in both mutants: a substitution of cysteine for arginine 168 [2].
Formation of flagella lacking outer rings by flaM, flaU, and flaY mutants of Escherichia coli [3].
This hypothesis is supported by the phenotype of an unusual flaU mutant, which represses even though it is unable to promote flagellar assembly [4].

References

Structural genes for flagellar hook-associated proteins in Salmonella typhimurium. Homma, M., Kutsukake, K., Iino, T. J. Bacteriol. (1985) [Pubmed]
A mutant hook-associated protein (HAP3) facilitates torsionally induced transformations of the flagellar filament of Escherichia coli. Fahrner, K.A., Block, S.M., Krishnaswamy, S., Parkinson, J.S., Berg, H.C. J. Mol. Biol. (1994) [Pubmed]
Formation of flagella lacking outer rings by flaM, flaU, and flaY mutants of Escherichia coli. Ohnishi, K., Homma, M., Kutsukake, K., Iino, T. J. Bacteriol. (1987) [Pubmed]
Transcriptional control of flagellar genes in Escherichia coli K-12. Komeda, Y. J. Bacteriol. (1986) [Pubmed]

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