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Gene Review

lacA  -  thiogalactoside acetyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0339, JW0333
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Disease relevance of lacA


High impact information on lacA


Biological context of lacA

  • Our findings indicate that the natural polarity of the operon (lacZ is expressed sixfold more strongly than lacA) is based on posttranslational effects and not on polarity of transcription [3].

Associations of lacA with chemical compounds


Other interactions of lacA

  • These results support data regarding the natural polarity between lacZ versus lacA, the downstream gene [5].

Analytical, diagnostic and therapeutic context of lacA


  1. Identification, mapping, and cloning of the gene encoding cyanase in Escherichia coli K-12. Sung, Y.C., Parsell, D., Anderson, P.M., Fuchs, J.A. J. Bacteriol. (1987) [Pubmed]
  2. DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region. Hediger, M.A., Johnson, D.F., Nierlich, D.P., Zabin, I. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Transcription and decay of the lac messenger: role of an intergenic terminator. Murakawa, G.J., Kwan, C., Yamashita, J., Nierlich, D.P. J. Bacteriol. (1991) [Pubmed]
  4. Lactose metabolism by Staphylococcus aureus: characterization of lacABCD, the structural genes of the tagatose 6-phosphate pathway. Rosey, E.L., Oskouian, B., Stewart, G.C. J. Bacteriol. (1991) [Pubmed]
  5. Polarity effects in the lactose operon of Escherichia coli. Li, Y., Altman, S. J. Mol. Biol. (2004) [Pubmed]
  6. The amino acid sequence of thiogalactoside transacetylase of Escherichia coli. Fowler, A.V., Hediger, M.A., Musso, R.E., Zabin, I. Biochimie (1985) [Pubmed]
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