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Gene Review

sufC  -  SufBCD Fe-S cluster assembly scaffold...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1678, JW1672, ynhD
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Disease relevance of sufC


High impact information on sufC

  • Virulence tests showed that sufA and sufC mutants exhibited reduced ability to cause maceration of chicory leaves, whereas a functional sufC gene was necessary for the bacteria to cause systemic invasion of Saintpaulia ionantha [1].
  • In addition, inactivation of sufC and sufD led to increased sensitivity to paraquat [1].
  • The sufB and sufC genes that always occur together in bacteria are also found in plants, and even the malaria parasite, associated with the plastid organelle [2].


  1. SoxR-dependent response to oxidative stress and virulence of Erwinia chrysanthemi: the key role of SufC, an orphan ABC ATPase. Nachin, L., El Hassouni, M., Loiseau, L., Expert, D., Barras, F. Mol. Microbiol. (2001) [Pubmed]
  2. SufC hydrolyzes ATP and interacts with SufB from Thermotoga maritima. Rangachari, K., Davis, C.T., Eccleston, J.F., Hirst, E.M., Saldanha, J.W., Strath, M., Wilson, R.J. FEBS Lett. (2002) [Pubmed]
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