Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

fliN - flagellar motor switching and energizing...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1944, JW1930, motD

Nutsch, T. et al., Lloyd, S.A. et al., Roman, S.J. et al., Malakooti, J. et al., Simpson, D.A. et al.

Nutsch, Marwan, Oesterhelt, Gilles,

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Disease relevance of fliN

The flagellar motor switch in Escherichia coli and Salmonella typhimurium controls swimming behavior by regulating the direction of flagellar rotation [1].

High impact information on fliN

Light stimuli of defined intensity and time course can be controlled precisely, which facilitates input-output measurements used for system analysis of the molecular network connecting the sensory receptors to the flagellar motor switch [2].
Here, we analyze the response of halobacterial cells to single and double-pulse light stimuli and present the first kinetic model for prokaryotic cells that couples the signal-transduction pathway with the flagellar motor switch [2].
The fliN gene is flanked on its 5'-end by the 3'-end of a homolog of a fliM gene [3].
DNA sequence analysis of the motD gene revealed an open reading frame of 414 base pairs [4].

Anatomical context of fliN

Here, we present evidence that the reported mot mutations in fliM and fliN do not disrupt torque-generating functions specifically but, instead, affect the incorporation of proteins into the flagellum [5].

References

Gene sequence, overproduction, purification and determination of the wild-type level of the Escherichia coli flagellar switch protein FliG. Roman, S.J., Frantz, B.B., Matsumura, P. Gene (1993) [Pubmed]
Signal processing and flagellar motor switching during phototaxis of Halobacterium salinarum. Nutsch, T., Marwan, W., Oesterhelt, D., Gilles, E.D. Genome Res. (2003) [Pubmed]
Characterization of Pseudomonas aeruginosa fliO, a gene involved in flagellar biosynthesis and adherence. Simpson, D.A., Ramphal, R., Lory, S. Infect. Immun. (1995) [Pubmed]
DNA sequence analysis, gene product identification, and localization of flagellar motor components of Escherichia coli. Malakooti, J., Komeda, Y., Matsumura, P. J. Bacteriol. (1989) [Pubmed]
Torque generation in the flagellar motor of Escherichia coli: evidence of a direct role for FliG but not for FliM or FliN. Lloyd, S.A., Tang, H., Wang, X., Billings, S., Blair, D.F. J. Bacteriol. (1996) [Pubmed]

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