Disease relevance of Prokaryotic Cells

• It has previously been observed that Escherichia coli lon mutations increase the levels of enzymes involved in the synthesis of colanic acid capsular polysaccharide (A. Markovitz, p. 415-462, in I. Sutherland, ed., Surface Carbohydrates of the Prokaryotic Cell, 1977) [1].
• Molecular characterization of a family of choline-binding proteins of Clostridium beijerinckii NCIB 8052. Evolution and gene redundancy in prokaryotic cell [2].
• Genetic elements called retrons reside on the chromosome of Escherichia coli and the myxobacteria and represent the first reverse transcriptase-encoding element to be found in a prokaryotic cell [3].
• The ubiquitous presence of hsp70 in eukaryotic and prokaryotic cells, combined with its high degree of sequence homology and intrinsic immunogenicity, have prompted the suggestion that inappropriate immune reactivity to hsp70 might lead to pro-inflammatory responses and the development of autoimmune disease [4].
• Characterization of the glycoprotein D gene products of equine herpesvirus 1 using a prokaryotic cell expression vector [5].

High impact information on Prokaryotic Cells

• Membrane adenosine triphosphatases of prokaryotic cells [6].
• The structural elucidation of clear but distant homologs of actin and tubulin in bacteria and GFP labeling of these proteins promises to reinvigorate the field of prokaryotic cell biology [7].
• This points to an evolutionary parallel between DNA segregation and cytokinesis in prokaryotic cells, and reveals a potential molecular mechanism for plasmid and chromosome segregation mediated by the ubiquitous ParA-type proteins [8].
• Still unclear, however, is exactly why most eukaryotic cells, in contrast to prokaryotic cells, express a novel form of hsp 70 (i.e., hsp 72) after experiencing stress [9].
• Studies of deeply buried, sedimentary microbial communities and associated biogeochemical processes during Ocean Drilling Program Leg 201 showed elevated prokaryotic cell numbers in sediment layers where methane is consumed anaerobically at the expense of sulfate [10].

Chemical compound and disease context of Prokaryotic Cells

• Under moderate exposure conditions (high survival) it was found that bisulfite is not mutagenic to either eukaryotic cells (Chinese hamster V79), or prokaryotic cells (Escherichia coli) [11].

Biological context of Prokaryotic Cells

• The differences in molecular mass on SDS-PAGE are thought to be attributed to the acidic nature of the P protein (pI=6.27) and also the different degrees of phosphorylation in the prokaryotic cell [12].

Anatomical context of Prokaryotic Cells

• Interaction with the plasminogen system promotes damage of extracellular matrices as well as bacterial spread and organ invasion during infection, suggesting common mechanisms in migration of eukaryotic and prokaryotic cells [13].
• FtsH (HflB) is an ATP-dependent protease found in prokaryotic cells, mitochondria and chloroplasts [14].
• It is suggested that ascamycin cannot be transported through mammalian cell membranes but dealanylascamycin can permeate; a similar situation exists in prokaryotic cells [15].
• The 90 kDa heat shock protein Hsp90 is a highly conserved and very abundant protein in the cytosol of both eukaryotic and prokaryotic cells [16].

Associations of Prokaryotic Cells with chemical compounds

• Fumarate reductases and succinate dehydrogenases play central roles in the metabolism of eukaryotic and prokaryotic cells [17].
• In addition to Pi, it is also shown in this report that the synthesis of both PLC-H and PLC-N is induced by compounds which are not only derived from the substrate product of both enzymes, i.e. phosphorylcholine, but are also known osmoprotectants in eukaryotic and prokaryotic cells [18].
• These results suggest that it may be possible to use an arginine decarboxylase inhibitor in conjunction with known inhibitors of ornithine decarboxylase to block all putrescine biosynthesis in prokaryotic cells and thus to study the effects of such inhibition in these organisms [19].
• L-Carnitine (R-[-]-3-hydroxy-4-trimethylaminobutyrate) is found in both eukaryotic and prokaryotic cells and participates in diverse processes including long-chain fatty-acid transport and osmoprotection [20].
• Our results support the hypothesis [Williams, R.J.P. (1982) FEBS Lett. 140, 3-10] that prokaryotic cells may contain a standing pool of free or loosely bound Fe(II) that is capable of acting in a regulatory capacity [21].

Gene context of Prokaryotic Cells

• ARTEMIS represents a so-far-unrecognized link between prokaryotic cell fission and chloroplast division [22].
• The bFGF mutant (M1Q-bFGF) was expressed in eukaryotic cells and in prokaryotic cells, from which it was purified to homogeneity [23].
• Inhibition of prokaryotic cell growth by HIV1 Vpr [24].
• A gene coding for t-PA has been reconstructed and inserted into vectors for expression in prokaryotic cells [25].
• An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins [26].

References