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Gene Review

Z3235m  -  sensor protein

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of Z3235m

 

Psychiatry related information on Z3235m

 

High impact information on Z3235m

 

Chemical compound and disease context of Z3235m

 

Biological context of Z3235m

 

Anatomical context of Z3235m

 

Associations of Z3235m with chemical compounds

 

Regulatory relationships of Z3235m

 

Other interactions of Z3235m

  • In bacteria and archaea the Amt structural genes (amtB) are invariably linked to glnK, which encodes a member of the P(II) signal transduction protein family, proteins that regulate many facets of nitrogen metabolism [31].
  • It has been previously shown that the EPEC eaeB (espB) gene encodes a secreted protein required for signal transduction and adherence, while eaeA encodes intimin, an EPEC membrane protein that mediates intimate adherence and contributes to focusing of cytoskeletal proteins beneath bacteria [32].
  • It is concluded that espA encodes an EPEC secreted protein that is necessary for activating epithelial signal transduction, intimate contact, and formation of attaching and effacing lesions, processes which are central to pathogenesis [32].
  • We constructed a nonpolar mutation in espD and found that the mutant is incapable of the signal transduction events that lead to activation of the putative intimin receptor in host cells and that the mutant fails to induce the attaching and effacing effect [33].
  • We have reconstituted the signal transduction system responsible for the negative regulation of the transcription of the Escherichia coli glnA gene, encoding glutamine synthetase, by glutamine [34].
 

Analytical, diagnostic and therapeutic context of Z3235m

References

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  24. Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon. Tuomanen, E., Lindquist, S., Sande, S., Galleni, M., Light, K., Gage, D., Normark, S. Science (1991) [Pubmed]
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  29. Guanylin stimulates regulated secretion from human neuroendocrine pancreatic cells. John, M., Wiedenmann, B., Kruhøffer, M., Adermann, K., Ankorina-Stark, I., Schlatter, E., Ahnert-Hilger, G., Forssmann, W.G., Kuhn, M. Gastroenterology (1998) [Pubmed]
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  33. A third secreted protein that is encoded by the enteropathogenic Escherichia coli pathogenicity island is required for transduction of signals and for attaching and effacing activities in host cells. Lai, L.C., Wainwright, L.A., Stone, K.D., Donnenberg, M.S. Infect. Immun. (1997) [Pubmed]
  34. Reversible uridylylation of the Escherichia coli PII signal transduction protein regulates its ability to stimulate the dephosphorylation of the transcription factor nitrogen regulator I (NRI or NtrC). Atkinson, M.R., Kamberov, E.S., Weiss, R.L., Ninfa, A.J. J. Biol. Chem. (1994) [Pubmed]
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