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Gene Review

amiA  -  N-acetylmuramoyl-l-alanine amidase I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2430, JW2428, yfeE
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Disease relevance of amiA


High impact information on amiA

  • To investigate this effect, wild type, mutant, and revertant DNA sequences at five genetic sites within the amiA locus were determined [3].
  • Analysis of the amiA and amiC coding sequences indicates that the proteins may be synthesized with plausible twin-arginine signal sequences, and we demonstrate that they are translocated to the periplasm by the Tat pathway [4].
  • Deletion mutants in amiA, B and C were growing in long chains of unseparated cells and displayed a tolerant response to the normally lytic combination of aztreonam and bulgecin [5].
  • Furthermore, we identified by DNA sequencing several other biocatalyst-encoding genes, including genes encoding a putative stereoselective amidase (amiA), two cellulases (gnuB and uvs080), an alpha-amylase (amyA), a 1,4-alpha-glucan branching enzyme (amyB), and two pectate lyases (pelA and uvs119) [6].


  1. The difficulty of cloning Streptococcus pneumoniae mal and ami loci in Escherichia coli: toxicity of malX and amiA gene products. Martin, B., Alloing, G., Boucraut, C., Claverys, J.P. Gene (1989) [Pubmed]
  2. The Bacillus subtilis lipoprotein LplA causes cell lysis when expressed in Escherichia coli. Gómez, A., Ramón, D., Sanz, P. Microbiology (Reading, Engl.) (1994) [Pubmed]
  3. Mismatch repair in Streptococcus pneumoniae: relationship between base mismatches and transformation efficiencies. Claverys, J.P., Méjean, V., Gasc, A.M., Sicard, A.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  4. Role of the Escherichia coli Tat pathway in outer membrane integrity. Ize, B., Stanley, N.R., Buchanan, G., Palmer, T. Mol. Microbiol. (2003) [Pubmed]
  5. Involvement of N-acetylmuramyl-L-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli. Heidrich, C., Templin, M.F., Ursinus, A., Merdanovic, M., Berger, J., Schwarz, H., de Pedro, M.A., Höltje, J.V. Mol. Microbiol. (2001) [Pubmed]
  6. Prospecting for novel biocatalysts in a soil metagenome. Voget, S., Leggewie, C., Uesbeck, A., Raasch, C., Jaeger, K.E., Streit, W.R. Appl. Environ. Microbiol. (2003) [Pubmed]
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