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Gene Review:

rnc - RNase III

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2565, JW2551, ranA

Sun, W. et al., Sun, W. et al., Matsunaga, J. et al., Pertzev, A.V. et al., March, P.E. et al., et al.

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Disease relevance of rnc

DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations [1].
Ribonuclease III cleavage of a bacteriophage T7 processing signal. Divalent cation specificity, and specific anion effects [2].

High impact information on rnc

Moreover, mutations in rncO that block RNase III cleavage also block control, showing that RNase III initiates mRNA decay by cleaving at a single site [3].
A conserved sequence element in ribonuclease III processing signals is not required for accurate in vitro enzymatic cleavage [4].
The DNA sequence of a 1,076 base pair BglI-BamHI fragment containing the entire rnc gene for ribonuclease III (RNase III) was determined [5].
The ribonuclease III superfamily represents a structurally distinct group of double-strand-specific endonucleases with essential roles in RNA maturation, RNA decay, and gene silencing [6].
Members of the ribonuclease III family are the primary agents of double-stranded (ds) RNA processing in prokaryotic and eukaryotic cells [7].

Biological context of rnc

Catalytic mechanism of Escherichia coli ribonuclease III: kinetic and inhibitor evidence for the involvement of two magnesium ions in RNA phosphodiester hydrolysis [8].

References

DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations. Nashimoto, H., Uchida, H. Mol. Gen. Genet. (1985) [Pubmed]
Ribonuclease III cleavage of a bacteriophage T7 processing signal. Divalent cation specificity, and specific anion effects. Li, H.L., Chelladurai, B.S., Zhang, K., Nicholson, A.W. Nucleic Acids Res. (1993) [Pubmed]
Expression and regulation of the rnc and pdxJ operons of Escherichia coli. Matsunaga, J., Dyer, M., Simons, E.L., Simons, R.W. Mol. Microbiol. (1996) [Pubmed]
A conserved sequence element in ribonuclease III processing signals is not required for accurate in vitro enzymatic cleavage. Chelladurai, B.S., Li, H., Nicholson, A.W. Nucleic Acids Res. (1991) [Pubmed]
The DNA sequence of the gene (rnc) encoding ribonuclease III of Escherichia coli. March, P.E., Ahnn, J., Inouye, M. Nucleic Acids Res. (1985) [Pubmed]
Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro. Sun, W., Li, G., Nicholson, A.W. Biochemistry (2004) [Pubmed]
Characterization of RNA sequence determinants and antideterminants of processing reactivity for a minimal substrate of Escherichia coli ribonuclease III. Pertzev, A.V., Nicholson, A.W. Nucleic Acids Res. (2006) [Pubmed]
Catalytic mechanism of Escherichia coli ribonuclease III: kinetic and inhibitor evidence for the involvement of two magnesium ions in RNA phosphodiester hydrolysis. Sun, W., Pertzev, A., Nicholson, A.W. Nucleic Acids Res. (2005) [Pubmed]

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