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Gene Review

pheA  -  chorismate mutase and prephenate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2596, JW2580
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Disease relevance of pheA


High impact information on pheA

  • Two classes of mutants affecting the regulation of pheA expression in Escherichia coli have been reported previously: trans-acting mutants involving the locus pheR, and cis-acting mutants involving the locus pheAo [1].
  • Both pheAo351 and pheAo352 contained a G:C to A:T base pair transition, at different positions in the 3:4 stem of the pheA attenuator terminator [1].
  • The phe operon consists of promoter, operator, leader region containing the phe attenuator and the pheA gene encoding chorismate mutase/prephenate dehydratase [2].
  • In these clones, chromosomally located Tn4652 was transposed upstream from the coding sequencing of pheA (encoding phenol monooxygenase) [3].
  • Lon-directed degradation of SulA was energy dependent, as was the increase in degradation of SulA in delta lon pAlp+ cells. alp maps close to pheA, at 57 min on the E. coli chromosome [4].

Chemical compound and disease context of pheA


Anatomical context of pheA

  • To understand the factors that determine the basal level of pheA expression, we examined the role of ribosome release from the leader peptide stop codon UGA [5].


  1. pheAo mutants of Escherichia coli have a defective pheA attenuator. Gavini, N., Davidson, B.E. J. Biol. Chem. (1990) [Pubmed]
  2. Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12. Hudson, G.S., Davidson, B.E. J. Mol. Biol. (1984) [Pubmed]
  3. In-vivo-generated fusion promoters in Pseudomonas putida. Nurk, A., Tamm, A., Hôrak, R., Kivisaar, M. Gene (1993) [Pubmed]
  4. Alp, a suppressor of lon protease mutants in Escherichia coli. Trempy, J.E., Gottesman, S. J. Bacteriol. (1989) [Pubmed]
  5. Role of ribosome release in the basal level of expression of the Escherichia coli gene pheA. Gavini, N., Pulakat, L. J. Gen. Microbiol. (1991) [Pubmed]
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