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Gene Review

pheU  -  tRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4128, JWR0111, pheR, pheW
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Disease relevance of pheU


High impact information on pheU

  • In Escherichia coli, the expression of the phenylalanine biosynthetic enzyme chorismate mutase/prephenate dehydratase, encoded by pheA, is elevated in strains carrying pheR mutants [2].
  • Using proteomic and microarray analysis, we identified for the first time that AggR activates the expression of chromosomal genes, including 25 contiguous genes (aaiA-Y), which are localized to a 117 kb pathogenicity island (PAI) inserted at pheU [3].
  • Nucleotide sequence of pheW; a third gene for E. coli tRNAPhe [4].
  • Strains deleted for this integrase demonstrated a reduction in the insertion frequency of plasmids harboring only the DR into the pheU locus [5].
  • Recombinant plasmids harboring a single direct repeat cloned either with or without the LEE O26 integrase gene were found to insert within the chromosomal pheU locus of E. coli K-12 strains with equal efficiency, suggesting that an endogenous P4-like integrase can substitute for this activity [5].

Other interactions of pheU

  • Similar derepression of pheA has been reported in pheR mutants of E. coli K-12 (J. Gowrishankar and J. Pittard, J. Bacteriol. 150:1130-1137, 1982) [6].

Analytical, diagnostic and therapeutic context of pheU


  1. The pheR gene of Escherichia coli encodes tRNA(Phe), not a repressor protein. Gavini, N., Davidson, B.E. J. Biol. Chem. (1990) [Pubmed]
  2. Regulation of pheA expression by the pheR product in Escherichia coli is mediated through attenuation of transcription. Gavini, N., Davidson, B.E. J. Biol. Chem. (1991) [Pubmed]
  3. Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Dudley, E.G., Thomson, N.R., Parkhill, J., Morin, N.P., Nataro, J.P. Mol. Microbiol. (2006) [Pubmed]
  4. Nucleotide sequence of pheW; a third gene for E. coli tRNAPhe. Wilson, R.K., Brown, T., Roe, B.A. Nucleic Acids Res. (1986) [Pubmed]
  5. Active genetic elements present in the locus of enterocyte effacement in Escherichia coli O26 and their role in mobility. Muniesa, M., Schembri, M.A., Hauf, N., Chakraborty, T. Infect. Immun. (2006) [Pubmed]
  6. Evidence that there are only two tRNA(Phe) genes in Escherichia coli. Pittard, J., Praszkier, J., Certoma, A., Eggertsson, G., Gowrishankar, J., Narasaiah, G., Whipp, M.J. J. Bacteriol. (1990) [Pubmed]
  7. Molecular cloning of pheR in Escherichia coli K-12. Gowrishankar, J., Pittard, J. J. Bacteriol. (1982) [Pubmed]
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