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Gene Review

tyrA  -  fused chorismate mutase T/prephenate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2597, JW2581
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Disease relevance of tyrA

  • Fragments of the tyrA gene of Escherichia coli, when suitably engineered, can express either the chorismate mutase activity or the prephenate dehydrogenase activity without the other [1].
  • As one example of advantageous biochemical potential, the presence of CM-F in Salmonella typhimurium increases the capacity for prephenate accumulation in a tyrA auxotroph [2].

High impact information on tyrA

  • The tyr operon consists of promoter, operator, a short leader region without an attenuator, and two structural genes aroF and tyrA encoding the tyrosine-sensitive isoenzyme of 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) synthetase and chorismate mutase/prephenate dehydrogenase, respectively [3].


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