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Gene Review

trkA  -  NAD-binding component of TrK potassium...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3276, JW3251, sapG
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Disease relevance of trkA


High impact information on trkA

  • A trkA isogenic mutant was constructed via insertional inactivation, and it was significantly more easily killed by human serum, protamine, or polymyxin B than was the wild type [2].
  • Two adjacent genes, named trkA (1,374 bp) and trkH (1,449 bp), were identified on an 8.5-kb DNA fragment, while a third gene, called trkI (1,479 bp), located at a different site in the H. elongata chromosome, was found on a second 8.5-kb fragment [3].
  • The potential protein expressed by trkA is similar to the cytoplasmic NAD+/NADH binding protein TrkA from E. coli, which is required for the activity of the Trk K+ uptake system [3].

Analytical, diagnostic and therapeutic context of trkA

  • Reverse transcriptase PCR experiments and Northern hybridization analyses of the trkAH locus revealed cotranscription of trkAH as well as a monocistronic transcript with only trkA [3].


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