The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

avtA  -  valine-pyruvate aminotransferase;...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3561, JW5652
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of avtA

  • The avtA (alanine-valine transaminase) gene of E. coli K-12 was sequenced by this approach [1].
 

High impact information on avtA

  • avtA, which encodes the alanine-valine transaminase, transaminase C, was cloned in vivo with high- and low-copy-number mini-Mu cloning vectors [2].
  • We hypothesize that this is due to repression of avtA by the elevated alanine and leucine pools found in amino acid-starved cells [3].
  • The data indicated that avtA is the structural gene for transaminase C, that transaminase C is a single enzyme species, and that the sole pathway for pantothenate biosynthesis is from alpha-ketoisovalerate [4].
 

Chemical compound and disease context of avtA

  • In Salmonella typhimurium, as in Escherichia coli, mutations in avtA, the gene encoding the alanine-valine transaminase (transaminase C), are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis. avtA is repressed by leucine or alanine but not by valine [3].

References

  1. Rapid sequencing of cloned DNA using a transposon for bidirectional priming: sequence of the Escherichia coli K-12 avtA gene. Liu, L., Whalen, W., Das, A., Berg, C.M. Nucleic Acids Res. (1987) [Pubmed]
  2. Cloning and characterization of the Escherichia coli K-12 alanine-valine transaminase (avtA) gene. Wang, M.D., Liu, L., Wang, B.M., Berg, C.M. J. Bacteriol. (1987) [Pubmed]
  3. Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant. Berg, C.M., Whalen, W.A., Archambault, L.B. J. Bacteriol. (1983) [Pubmed]
  4. Analysis of an avtA::Mu d1(Ap lac) mutant: metabolic role of transaminase C. Whalen, W.A., Berg, C.M. J. Bacteriol. (1982) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities