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Gene Review

ilvN  -  acetolactate synthase 1 small subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3661, JW3645
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Disease relevance of ilvN

  • We have cloned the two subunits, ilvB and ilvN, of this Escherichia coli isoenzyme and examined the enzymatic properties of the purified holoenzyme and the enzyme reconstituted from purified subunits [1].
  • Acetolactate synthase small subunit encoding ilvN genes from the parental Streptomyces cinnamonensis strain and mutants resistant either to valine analogues or to 2-ketobutyrate were cloned and sequenced [2].

High impact information on ilvN

  • We reserve the designation ilvB for the promoter proximal (longer) cistron and designate the promoter distal cistron ilvN [3].
  • Changes in the sequence of ilvN conferring the insensitivity to valine in mutant strains were found in two distinct regions [2].

Biological context of ilvN


  1. Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties. Vinogradov, V., Vyazmensky, M., Engel, S., Belenky, I., Kaplun, A., Kryukov, O., Barak, Z., Chipman, D.M. Biochim. Biophys. Acta (2006) [Pubmed]
  2. Mutations in two distinct regions of acetolactate synthase regulatory subunit from Streptomyces cinnamonensis result in the lack of sensitivity to end-product inhibition. Kopecký, J., Janata, J., Pospísil, S., Felsberg, J., Spízek, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  3. The ilvB locus of Escherichia coli K-12 is an operon encoding both subunits of acetohydroxyacid synthase I. Friden, P., Donegan, J., Mullen, J., Tsui, P., Freundlich, M., Eoyang, L., Weber, R., Silverman, P.M. Nucleic Acids Res. (1985) [Pubmed]
  4. Cloning and phylogenetic analysis of the genes encoding acetohydroxyacid synthase from the archaeon Methanococcus aeolicus. Bowen, T.L., Union, J., Tumbula, D.L., Whitman, W.B. Gene (1997) [Pubmed]
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