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Gene Review:

hrpA - putative ATP-dependent helicase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1406, JW5905

Koo, J.T. et al., Chédin, F. et al., Moriya, H. et al., Hienonen, E. et al.

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Disease relevance of hrpA

Cloning and characterization of the hrpA gene in the terC region of Escherichia coli that is highly similar to the DEAH family RNA helicase genes of Saccharomyces cerevisiae [1].
Transcript stabilization by mRNA sequences from hrpA of Pseudomonas syringae [2].
The Bacillus subtilis AddAB enzyme possesses ATP-dependent helicase and nuclease activities, which result in the unwinding and degradation of double-stranded DNA (dsDNA) upon translocation [3].

High impact information on hrpA

A putative DEAH-box RNA helicase-encoding gene at this position, hrpA, was able to restore the ability of the mutant to cleave daa mRNA [4].
Site-directed mutagenesis of the hrpA regions predicted to encode nucleotide triphosphate binding and hydrolysis functions abolished the ability of the gene to restore the processing defect in the mutant [4].

References

Cloning and characterization of the hrpA gene in the terC region of Escherichia coli that is highly similar to the DEAH family RNA helicase genes of Saccharomyces cerevisiae. Moriya, H., Kasai, H., Isono, K. Nucleic Acids Res. (1995) [Pubmed]
Transcript stabilization by mRNA sequences from hrpA of Pseudomonas syringae. Hienonen, E., Romantschuk, M., Fenel, F., Taira, S. J. Biotechnol. (2007) [Pubmed]
The AddAB helicase/nuclease forms a stable complex with its cognate chi sequence during translocation. Chédin, F., Handa, N., Dillingham, M.S., Kowalczykowski, S.C. J. Biol. Chem. (2006) [Pubmed]
HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli. Koo, J.T., Choe, J., Moseley, S.L. Mol. Microbiol. (2004) [Pubmed]

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