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Gene Review

rhlE  -  ATP-dependent RNA helicase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0786, JW0781
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Disease relevance of rhlE

  • A newly recognized gene we name rhlB, after RNA helicase-like genes, has been found in the 85-minute region of the Escherichia coli chromosome [1].
  • Exoribonuclease R interacts with endoribonuclease E and an RNA helicase in the psychrotrophic bacterium Pseudomonas syringae Lz4W [2].
  • The plum pox potyvirus (PPV) protein CI is an RNA helicase whose function in the viral life cycle is still unknown [3].
  • These results indicate that motif V is involved in the NTP hydrolysis step required for potyvirus RNA helicase activity, and that this activity plays an essential role in virus RNA replication inside the infected cell [3].
  • The hepatitis C virus (HCV) nonstructural 3 protein (NS3) contains at least two domains associated with multiple enzymatic activities; a serine protease activity resides in the N-terminal one-third of the protein, whereas RNA helicase activity and RNA-stimulated nucleoside triphosphatase activity are associated with the C-terminal portion [4].

High impact information on rhlE


Chemical compound and disease context of rhlE


Biological context of rhlE


Anatomical context of rhlE


Associations of rhlE with chemical compounds

  • Moreover, both ATP and a non-hydrolyzable analog, ATPgammaS, support the PAP I and PNPase-dependent degradation of the 147-residue intermediate implying that ATPase activity, such as that which may reside in RhlB, a putative RNA helicase, is not necessarily required [15].
  • Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues [12].

Other interactions of rhlE


  1. rhlB, a new Escherichia coli K-12 gene with an RNA helicase-like protein sequence motif, one of at least five such possible genes in a prokaryote. Kalman, M., Murphy, H., Cashel, M. New Biol. (1991) [Pubmed]
  2. Exoribonuclease R interacts with endoribonuclease E and an RNA helicase in the psychrotrophic bacterium Pseudomonas syringae Lz4W. Purusharth, R.I., Klein, F., Sulthana, S., Jäger, S., Jagannadham, M.V., Evguenieva-Hackenberg, E., Ray, M.K., Klug, G. J. Biol. Chem. (2005) [Pubmed]
  3. The motif V of plum pox potyvirus CI RNA helicase is involved in NTP hydrolysis and is essential for virus RNA replication. Fernández, A., Guo, H.S., Sáenz, P., Simón-Buela, L., Gómez de Cedrón, M., García, J.A. Nucleic Acids Res. (1997) [Pubmed]
  4. Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. Gallinari, P., Brennan, D., Nardi, C., Brunetti, M., Tomei, L., Steinkühler, C., De Francesco, R. J. Virol. (1998) [Pubmed]
  5. Massive presence of the Escherichia coli 'major cold-shock protein' CspA under non-stress conditions. Brandi, A., Spurio, R., Gualerzi, C.O., Pon, C.L. EMBO J. (1999) [Pubmed]
  6. ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Blum, S., Schmid, S.R., Pause, A., Buser, P., Linder, P., Sonenberg, N., Trachsel, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. The RNase E of Escherichia coli has at least two binding sites for DEAD-box RNA helicases: functional replacement of RhlB by RhlE. Khemici, V., Toesca, I., Poljak, L., Vanzo, N.F., Carpousis, A.J. Mol. Microbiol. (2004) [Pubmed]
  8. HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli. Koo, J.T., Choe, J., Moseley, S.L. Mol. Microbiol. (2004) [Pubmed]
  9. The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. Li, H., Clum, S., You, S., Ebner, K.E., Padmanabhan, R. J. Virol. (1999) [Pubmed]
  10. RNA helicase activity of Semliki Forest virus replicase protein NSP2. Gomez de Cedrón, M., Ehsani, N., Mikkola, M.L., García, J.A., Kääriäinen, L. FEBS Lett. (1999) [Pubmed]
  11. Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor. Lewis, L.K., Jenkins, M.E., Mount, D.W. J. Bacteriol. (1992) [Pubmed]
  12. Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues. Yang, L., Liu, Z.R. Protein Expr. Purif. (2004) [Pubmed]
  13. CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit. Charollais, J., Dreyfus, M., Iost, I. Nucleic Acids Res. (2004) [Pubmed]
  14. The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. Charollais, J., Pflieger, D., Vinh, J., Dreyfus, M., Iost, I. Mol. Microbiol. (2003) [Pubmed]
  15. Reconstitution of the degradation of the mRNA for ribosomal protein S20 with purified enzymes. Coburn, G.A., Mackie, G.A. J. Mol. Biol. (1998) [Pubmed]
  16. Cloning and characterization of the hrpA gene in the terC region of Escherichia coli that is highly similar to the DEAH family RNA helicase genes of Saccharomyces cerevisiae. Moriya, H., Kasai, H., Isono, K. Nucleic Acids Res. (1995) [Pubmed]
  17. Low temperature regulated DEAD-box RNA helicase from the Antarctic archaeon, Methanococcoides burtonii. Lim, J., Thomas, T., Cavicchioli, R. J. Mol. Biol. (2000) [Pubmed]
  18. RNA helicase activity of the plum pox potyvirus CI protein expressed in Escherichia coli. Mapping of an RNA binding domain. Fernández, A., Laín, S., García, J.A. Nucleic Acids Res. (1995) [Pubmed]
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