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Gene Review:

dut - deoxyuridinetriphosphatase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3630, JW3615, dnaS, sof

Lundberg, L.G. et al., Lundberg, L.G. et al., Lari, S.U. et al.

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Disease relevance of dut

Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance [1].
To test the hypothesis that the SacI cleavage used affects a control region for the dut gene, we recloned the dut fragment by transferring it from pKK141 into pHUB2 (Bernard et al., Gene 5 (1979) 59-76), a plasmid carrying the phage lambda pL promoter [2].

High impact information on dut

We have constructed thermoinducible plasmids carrying the gene (dut) for the enzyme deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23) from Escherichia coli [2].

Biological context of dut

A 9.4-kb BamHI restriction enzyme fragment carrying the dut gene was inserted into the runaway-replication plasmid pKN402A (Uhlin et al., Gene 6 (1979) 91-106) [2].

Analytical, diagnostic and therapeutic context of dut

Isolation and characterization of the dut gene of Escherichia coli. II. Restriction enzyme mapping and analysis of polypeptide products [3].

References

Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance. Lari, S.U., Chen, C.Y., Vert??ssy, B.G., Morr??, J., Bennett, S.E. DNA Repair (Amst.) (2006) [Pubmed]
Isolation and characterization of the dut gene of Escherichia coli. I. Cloning in thermoinducible plasmids. Lundberg, L.G., Karlström, O.H., Nyman, P.O., Neuhard, J. Gene (1983) [Pubmed]
Isolation and characterization of the dut gene of Escherichia coli. II. Restriction enzyme mapping and analysis of polypeptide products. Lundberg, L.G., Karlström, O.H., Nyman, P.O. Gene (1983) [Pubmed]

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