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Gene Review

ung  -  uracil-DNA-glycosylase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2578, JW2564
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Disease relevance of ung


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Biological context of ung


Associations of ung with chemical compounds


Analytical, diagnostic and therapeutic context of ung


  1. Sequence analysis, expression, and conservation of Escherichia coli uracil DNA glycosylase and its gene (ung). Varshney, U., Hutcheon, T., van de Sande, J.H. J. Biol. Chem. (1988) [Pubmed]
  2. Site-directed mutagenesis and characterization of uracil-DNA glycosylase inhibitor protein. Role of specific carboxylic amino acids in complex formation with Escherichia coli uracil-DNA glycosylase. Lundquist, A.J., Beger, R.D., Bennett, S.E., Bolton, P.H., Mosbaugh, D.W. J. Biol. Chem. (1997) [Pubmed]
  3. Use of a coupled transcriptional system for consistent overexpression and purification of UDG-Ugi complex and Ugi from Escherichia coli. Roy, S., Purnapatre, K., Handa, P., Boyanapalli, M., Varshney, U. Protein Expr. Purif. (1998) [Pubmed]
  4. Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. Lu, C.C., Huang, H.T., Wang, J.T., Slupphaug, G., Li, T.K., Wu, M.C., Chen, Y.C., Lee, C.P., Chen, M.R. J. Virol. (2007) [Pubmed]
  5. A mollicute (mycoplasma) DNA repair enzyme: purification and characterization of uracil-DNA glycosylase. Williams, M.V., Pollack, J.D. J. Bacteriol. (1990) [Pubmed]
  6. The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision. Amado, L., Kuzminov, A. J. Biol. Chem. (2006) [Pubmed]
  7. Uracil-DNA glycosylase inhibitor gene of bacteriophage PBS2 encodes a binding protein specific for uracil-DNA glycosylase. Wang, Z., Mosbaugh, D.W. J. Biol. Chem. (1989) [Pubmed]
  8. Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance. Lari, S.U., Chen, C.Y., Vert??ssy, B.G., Morr??, J., Bennett, S.E. DNA Repair (Amst.) (2006) [Pubmed]
  9. Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited. Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L. Proteins (1999) [Pubmed]
  10. Construction and characterization of a library of metallothionein coding sequence mutants. Pine, R., Cismowski, M., Liu, S.W., Huang, P.C. DNA (1985) [Pubmed]
  11. Uracil-DNA glycosylase causes 5-bromodeoxyuridine photosensitization in Escherichia coli K-12. Yamamoto, Y., Fujiwara, Y. J. Bacteriol. (1990) [Pubmed]
  12. Antimutator role of the DNA glycosylase mutY gene in Helicobacter pylori. Huang, S., Kang, J., Blaser, M.J. J. Bacteriol. (2006) [Pubmed]
  13. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. Putnam, C.D., Shroyer, M.J., Lundquist, A.J., Mol, C.D., Arvai, A.S., Mosbaugh, D.W., Tainer, J.A. J. Mol. Biol. (1999) [Pubmed]
  14. Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase. Werner, R.M., Jiang, Y.L., Gordley, R.G., Jagadeesh, G.J., Ladner, J.E., Xiao, G., Tordova, M., Gilliland, G.L., Stivers, J.T. Biochemistry (2000) [Pubmed]
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