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Gene Review

lysU  -  lysine tRNA synthetase, inducible

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4123, JW4090
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Disease relevance of lysU


High impact information on lysU

  • In contrast to the recent proposal of Gampel and Tzagoloff (1989, Proc. Natl. Acad. Sci. USA 86, 6023-6027), the lysU sequence is distinct from the open reading frame located adjacent to frdA, although large homologies are shared by these two genes [1].
  • These mutations nullified the hns gene encoding a histone-like protein, H-NS, and affected thermoregulation of lysU [2].
  • A novel class of lysU-constitutive mutations were isolated by random insertion mutagenesis [2].
  • Accumulation of high levels of LysU during growth of strains carrying the wild-type allele of lysU on multicopy plasmids had no observable effect on growth or on the synthesis of LysS [3].
  • Pyridoxal 5'-phosphate (PLP) and pyridoxal 5'-diphosphate (PLDP) were used to identify lysyl residues at the phosphate-binding locus in the lysS-encoded and the lysU-encoded lysyl-tRNA synthetases (LysRSs and LysRSu, respectively) from Escherichia coli [4].

Chemical compound and disease context of lysU

  • The first threedimensional structure of a lysyl-tRNA synthetase worked out very recently, using the enzyme from the Escherichia coli lysU gene which binds one molecule of lysine, is similar to those of other class II synthetases [5].


  1. Homology of lysS and lysU, the two Escherichia coli genes encoding distinct lysyl-tRNA synthetase species. Lévêque, F., Plateau, P., Dessen, P., Blanquet, S. Nucleic Acids Res. (1990) [Pubmed]
  2. Regulation of lysyl-tRNA synthetase expression by histone-like protein H-NS of Escherichia coli. Ito, K., Oshima, T., Mizuno, T., Nakamura, Y. J. Bacteriol. (1994) [Pubmed]
  3. Roles of the two lysyl-tRNA synthetases of Escherichia coli: analysis of nucleotide sequences and mutant behavior. Clark, R.L., Neidhardt, F.C. J. Bacteriol. (1990) [Pubmed]
  4. Affinity labeling of Escherichia coli lysyl-tRNA synthetase with pyridoxal mono- and diphosphate. Hountondji, C., Gillet, S., Schmitter, J.M., Fukui, T., Blanquet, S. J. Biochem. (1994) [Pubmed]
  5. Lysyl-tRNA synthetase. Freist, W., Gauss, D.H. Biol. Chem. Hoppe-Seyler (1995) [Pubmed]
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