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MeSH Review

Body Temperature Regulation

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Disease relevance of Body Temperature Regulation


Psychiatry related information on Body Temperature Regulation


High impact information on Body Temperature Regulation

  • Targeted disruption of the MC5-R produced mice with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids [11].
  • Our findings strongly suggest that defects in TRKA cause CIPA and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans [12].
  • We find that UCP-deficient mice consume less oxygen after treatment with a beta3-adrenergic-receptor agonist and that they are sensitive to cold, indicating that their thermoregulation is defective [13].
  • We have now identified and characterized a new regulatory locus (drdX) and show that a histone-like bacterial protein has an important role in this novel example of thermoregulation of transcription [14].
  • The fimbrial structures (pili) on the bacterial surface carry the adhesin and are present during growth at 37 degrees C but are not produced by cells at lower temperatures, such as 25 degrees C. Thermoregulation of expression is due to temperature-dependent transcription of a regulatory cistron in the pilus-adhesin gene cluster [14].

Chemical compound and disease context of Body Temperature Regulation


Biological context of Body Temperature Regulation


Anatomical context of Body Temperature Regulation


Associations of Body Temperature Regulation with chemical compounds

  • The fever may arise from the drug's pharmacologic action, its effects on thermoregulation, a local complication following parenteral administration, or an idiosyncratic response [29].
  • Expression of melatonin receptors in arteries involved in thermoregulation [30].
  • Studies in animals suggest that medullary raphé neurons are essential for cold-defense, mediating both the cutaneous vasoconstrictor and thermogenic responses to ambient cooling; however, the involvement of raphé neurons in human thermoregulation has not been investigated [31].
  • Previous data from our laboratory have indicated that 5-HT neuronal activity is unaffected by this manipulation, though 5-HT has been implicated specifically in thermoregulation [32].
  • These data indicate that ambient temperature has a significant affect on MDMA neurotoxicity, core temperature, and thermoregulation in rats [33].

Gene context of Body Temperature Regulation

  • As a result, Dgat(-/-) mice had impaired water repulsion and defective thermoregulation after water immersion [34].
  • These findings are consistent with the notion that UCP4 and UCP5 may be involved in tissue-specific thermoregulation and metabolic changes associated with nutritional status [35].
  • Starvation caused increased muscle and decreased BAT UCP3, suggesting that muscle assumes a larger role in thermoregulation during starvation [36].
  • We have obtained Elovl3-ablated mice and report here that, although cold-acclimated Elovl3-ablated mice experienced an increased heat loss due to impaired skin barrier, they were unable to hyperrecruit their brown adipose tissue [37].
  • These results suggest differential roles of BMCP1 and UCP2 in thermoregulation and aging [38].

Analytical, diagnostic and therapeutic context of Body Temperature Regulation


  1. Energy metabolism in uncoupling protein 3 gene knockout mice. Vidal-Puig, A.J., Grujic, D., Zhang, C.Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., Muoio, D.M., Lowell, B.B. J. Biol. Chem. (2000) [Pubmed]
  2. Multiple copies of a DNA sequence from Pseudomonas syringae pathovar phaseolicola abolish thermoregulation of phaseolotoxin production. Rowley, K.B., Clements, D.E., Mandel, M., Humphreys, T., Patil, S.S. Mol. Microbiol. (1993) [Pubmed]
  3. Spontaneous periodic hypothermia. Mooradian, A.D., Morley, G.K., McGeachie, R., Lundgren, S., Morley, J.E. Neurology (1984) [Pubmed]
  4. Effects of ethanol on thermoregulation. Kalant, H., Lê, A.D. Pharmacol. Ther. (1983) [Pubmed]
  5. Effects of dopaminergic antagonist and agonist on thermoregulation in rabbits. Lin, M.T. J. Physiol. (Lond.) (1979) [Pubmed]
  6. Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. Yehuda, S., Carasso, R.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor. Ohki-Hamazaki, H., Sakai, Y., Kamata, K., Ogura, H., Okuyama, S., Watase, K., Yamada, K., Wada, K. J. Neurosci. (1999) [Pubmed]
  8. Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Franceschini, D., Paylor, R., Broide, R., Salas, R., Bassetto, L., Gotti, C., De Biasi, M. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  9. Serotonin receptors--where are they going? Leonard, B.E. International clinical psychopharmacology. (1994) [Pubmed]
  10. Nitric oxide and angiotensin II: neuromodulation of thermoregulation during combined heat and hypohydration stress. Schwimmer, H., Gerstberger, R., Horowitz, M. Brain Res. (2004) [Pubmed]
  11. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Chen, W., Kelly, M.A., Opitz-Araya, X., Thomas, R.E., Low, M.J., Cone, R.D. Cell (1997) [Pubmed]
  12. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Indo, Y., Tsuruta, M., Hayashida, Y., Karim, M.A., Ohta, K., Kawano, T., Mitsubuchi, H., Tonoki, H., Awaya, Y., Matsuda, I. Nat. Genet. (1996) [Pubmed]
  13. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Enerbäck, S., Jacobsson, A., Simpson, E.M., Guerra, C., Yamashita, H., Harper, M.E., Kozak, L.P. Nature (1997) [Pubmed]
  14. Transcriptional silencing and thermoregulation of gene expression in Escherichia coli. Göransson, M., Sondén, B., Nilsson, P., Dagberg, B., Forsman, K., Emanuelsson, K., Uhlin, B.E. Nature (1990) [Pubmed]
  15. Enhanced heat loss and age-related hypersensitivity to diazepam. Echizenya, M., Mishima, K., Satoh, K., Kusanagi, H., Sekine, A., Ohkubo, T., Shimizu, T., Hishikawa, Y. Journal of clinical psychopharmacology. (2004) [Pubmed]
  16. Differential effects of serotonin and raphe grafts in the hippocampus and hypothalamus: a combined behavioural and anatomical study in the rat. Richter-Levin, G., Acsády, L., Freund, T.F., Segal, M. Eur. J. Neurosci. (1994) [Pubmed]
  17. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Szallasi, A., Blumberg, P.M. Neuroscience (1989) [Pubmed]
  18. Effects of estrogen on food intake, body weight, and temperature of male and female obese mice. Dubuc, P.U. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  19. Functional, molecular and pharmacological advances in 5-HT7 receptor research. Hedlund, P.B., Sutcliffe, J.G. Trends Pharmacol. Sci. (2004) [Pubmed]
  20. Deregulation of temperature-dependent transcription of the invasion regulatory gene, virB, in Shigella by rho mutation. Tobe, T., Yoshikawa, M., Sasakawa, C. Mol. Microbiol. (1994) [Pubmed]
  21. Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. Panigrahy, A., Filiano, J., Sleeper, L.A., Mandell, F., Valdes-Dapena, M., Krous, H.F., Rava, L.A., Foley, E., White, W.F., Kinney, H.C. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  22. Effects of noradrenaline infused into the chick hypothalamus on thermoregulation below thermoneutrality. Marley, E., Stephenson, J.D. J. Physiol. (Lond.) (1975) [Pubmed]
  23. Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation. Rozhavskaya-Arena, M., Lee, D.W., Leinung, M.C., Grasso, P. Endocrinology (2000) [Pubmed]
  24. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Nisoli, E., Briscini, L., Giordano, A., Tonello, C., Wiesbrock, S.M., Uysal, K.T., Cinti, S., Carruba, M.O., Hotamisligil, G.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  25. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. Cartmell, T., Southgate, T., Rees, G.S., Castro, M.G., Lowenstein, P.R., Luheshi, G.N. J. Neurosci. (1999) [Pubmed]
  26. The effect of noradrenaline and 5-hydroxytryptamine injected into a lateral cerebral ventricle, on thermoregulation in the new-born lamb. Cooper, K.E., Pittman, Q.J., Veale, W.L. J. Physiol. (Lond.) (1976) [Pubmed]
  27. Cyclic adenosine 3', 5'-monophosphate in cerebrospinal fluid during thermoregulation and fever. Dascombe, M.J., Milton, A.S. J. Physiol. (Lond.) (1976) [Pubmed]
  28. Circulating serotonin in vertebrates. Maurer-Spurej, E. Cell. Mol. Life Sci. (2005) [Pubmed]
  29. Drug fever. Lipsky, B.A., Hirschmann, J.V. JAMA (1981) [Pubmed]
  30. Expression of melatonin receptors in arteries involved in thermoregulation. Viswanathan, M., Laitinen, J.T., Saavedra, J.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  31. Human medullary responses to cooling and rewarming the skin: a functional MRI study. McAllen, R.M., Farrell, M., Johnson, J.M., Trevaks, D., Cole, L., McKinley, M.J., Jackson, G., Denton, D.A., Egan, G.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  32. Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia. Wilkinson, L.O., Auerbach, S.B., Jacobs, B.L. J. Neurosci. (1991) [Pubmed]
  33. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. Malberg, J.E., Seiden, L.S. J. Neurosci. (1998) [Pubmed]
  34. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. Chen, H.C., Smith, S.J., Tow, B., Elias, P.M., Farese, R.V. J. Clin. Invest. (2002) [Pubmed]
  35. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. Yu, X.X., Mao, W., Zhong, A., Schow, P., Brush, J., Sherwood, S.W., Adams, S.H., Pan, G. FASEB J. (2000) [Pubmed]
  36. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. Gong, D.W., He, Y., Karas, M., Reitman, M. J. Biol. Chem. (1997) [Pubmed]
  37. ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. Westerberg, R., Månsson, J.E., Golozoubova, V., Shabalina, I.G., Backlund, E.C., Tvrdik, P., Retterstøl, K., Capecchi, M.R., Jacobsson, A. J. Biol. Chem. (2006) [Pubmed]
  38. Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Mizuno, T., Miura-Suzuki, T., Yamashita, H., Mori, N. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  39. The thermoregulatory threshold in humans during halothane anesthesia. Sessler, D.I., Olofsson, C.I., Rubinstein, E.H., Beebe, J.J. Anesthesiology (1988) [Pubmed]
  40. Heat loss reaction to capsaicin through a peripheral site of action. Donnerer, J., Lembeck, F. Br. J. Pharmacol. (1983) [Pubmed]
  41. Exposure to heat restores sleep in cats with preoptic/anterior hypothalamic cell loss. Szymusiak, R., Danowski, J., McGinty, D. Brain Res. (1991) [Pubmed]
  42. The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats. LoPachin, R.M., Rudy, T.A. Brain Res. (1981) [Pubmed]
  43. The facilitative effects of alpha-MSH and melanin on learning, thermoregulation, and pain in neonatal MSG-treated rats. Yehuda, S., Carasso, R.L., Mostofsky, D.I. Peptides (1991) [Pubmed]
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