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Gene Review

csgA  -  curlin subunit, amyloid curli fibers, cryptic

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1028, JW1025, agfA
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Disease relevance of csgA

  • The RpoS sigma factor relieves H-NS-mediated transcriptional repression of csgA, the subunit gene of fibronectin-binding curli in Escherichia coli [1].

High impact information on csgA

  • A third open reading frame, orfC, positioned downstream of csgA may affect some functional property of curli since an insertion in this putative gene abolishes the autoagglutinating ability typical of curliated cells without affecting the production of the fibre [2].
  • We show that the csgA gene which encodes the curlin subunit protein belongs to a dicistronic operon, csgBA [3].
  • In curli-deficient, RpoS- E. coli K-12 strains, csgA is transcriptionally activated by mutations in hns, which encodes the histone-like protein H-NS [1].
  • We show that the negative effect of the cpxA mutation on biofilm formation results from a decreased transcription of the curlin encoding csgA gene [4].
  • Curli were not present among several nonavian E. coli positive for crl and csgA [5].

Biological context of csgA

  • All isolates, irrespective of the production of the fimbriae, carried sequences specific for the structure (csgA) and for one of the regulator genes (crl) of curli expression, respectively [6].


  1. The RpoS sigma factor relieves H-NS-mediated transcriptional repression of csgA, the subunit gene of fibronectin-binding curli in Escherichia coli. Olsén, A., Arnqvist, A., Hammar, M., Sukupolvi, S., Normark, S. Mol. Microbiol. (1993) [Pubmed]
  2. Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12. Hammar, M., Arnqvist, A., Bian, Z., Olsén, A., Normark, S. Mol. Microbiol. (1995) [Pubmed]
  3. Sigma S-dependent growth-phase induction of the csgBA promoter in Escherichia coli can be achieved in vivo by sigma 70 in the absence of the nucleoid-associated protein H-NS. Arnqvist, A., Olsén, A., Normark, S. Mol. Microbiol. (1994) [Pubmed]
  4. Involvement of the Cpx signal transduction pathway of E. coli in biofilm formation. Dorel, C., Vidal, O., Prigent-Combaret, C., Vallet, I., Lejeune, P. FEMS Microbiol. Lett. (1999) [Pubmed]
  5. The occurrence of ambient temperature-regulated adhesins, curli, and the temperature-sensitive hemagglutinin tsh among avian Escherichia coli. Maurer, J.J., Brown, T.P., Steffens, W.L., Thayer, S.G. Avian Dis. (1998) [Pubmed]
  6. Curli expression of enterotoxigenic Escherichia coli. Szabó, E., Skedsmo, A., Sonnevend, A., Al-Dhaheri, K., Emody, L., Usmani, A., Pál, T. Folia Microbiol. (Praha) (2005) [Pubmed]
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