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Gene Review

cpxA  -  sensory histidine kinase in two-component...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3904, JW3882, ecfB, eup, rssE, ...
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Disease relevance of cpxA


High impact information on cpxA

  • Defined null mutations in cpxA or the gene encoding its cognate response regulator, cpxR, decrease transcription from degP [4].
  • Previous studies described lacZ'- and cat'-'cpxA fusion genes whose expression restored to normal all the phenotypic defects associated with cpxA mutations (Albin, R., and Silverman, P. M. (1984) Mol. Gen. Genet. 197, 272-279) [1].
  • The polypeptide showed temperature-sensitive accumulation in a strain carrying both the cpxA2[Ts] and cpxB1 alleles and accumulated to a level higher than normal in cells that carried a high-copy number, cpxA+ plasmid [1].
  • Using this information, we constructed a fusion gene containing the same 241 cpxA codons preceded by 1007 codons of beta-galactosidase [1].
  • The eup genetic locus of Escherichia coli and its role in H+/solute symport [5].

Chemical compound and disease context of cpxA


Biological context of cpxA


Anatomical context of cpxA


Associations of cpxA with chemical compounds

  • The amikacin resistance phenotype of the cpxA mutant was inseparable by recombination from the cpxA mutant phenotype (inability to grow at 41 degrees C without exogenous isoleucine and valine) and was recessive to the cpxA+ allele of a recombinant plasmid [8].
  • A mutation at the ssd locus resulted in elevated L-serine deaminase activity, inability to grow with succinate as the carbon source, and inability to grow anaerobic conditions [11].

Other interactions of cpxA

  • While a functional degP gene is required for full cpxA*-mediated suppression of both toxic envelope proteins, residual suppression is seen in cpxA* degP::Tn10 double mutants [2].
  • Two additional insertions were identified in genes sharing homology with the cpxA and damX genes from Escherichia coli K-12, and two uncharacterized invasion-deficient mutants were nonmotile [12].
  • We show that the negative effect of the cpxA mutation on biofilm formation results from a decreased transcription of the curlin encoding csgA gene [13].
  • Two transposon mutants with increased susceptibility to POA were found to harbor mutations in acnA encoding aconitase-1 and ygiY encoding a putative two-component sensor protein [14].

Analytical, diagnostic and therapeutic context of cpxA


  1. The Cpx proteins of Escherichia coli K12. Immunologic detection of the chromosomal cpxA gene product. Albin, R., Weber, R., Silverman, P.M. J. Biol. Chem. (1986) [Pubmed]
  2. Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses. Cosma, C.L., Danese, P.N., Carlson, J.H., Silhavy, T.J., Snyder, W.B. Mol. Microbiol. (1995) [Pubmed]
  3. Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay. Uhl, M.A., Miller, J.F. EMBO J. (1996) [Pubmed]
  4. The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP. Danese, P.N., Snyder, W.B., Cosma, C.L., Davis, L.J., Silhavy, T.J. Genes Dev. (1995) [Pubmed]
  5. The eup genetic locus of Escherichia coli and its role in H+/solute symport. Plate, C.A., Suit, J.L. J. Biol. Chem. (1981) [Pubmed]
  6. L-serine degradation in Escherichia coli K-12: directly isolated ssd mutants and their intragenic revertants. Newman, E.B., Malik, N., Walker, C. J. Bacteriol. (1982) [Pubmed]
  7. The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component. Weber, R.F., Silverman, P.M. J. Mol. Biol. (1988) [Pubmed]
  8. The Cpx proteins of Escherichia coli K-12: evidence that cpxA, ecfB, ssd, and eup mutations all identify the same gene. Rainwater, S., Silverman, P.M. J. Bacteriol. (1990) [Pubmed]
  9. Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. Pogliano, J., Dong, J.M., De Wulf, P., Furlong, D., Boyd, D., Losick, R., Pogliano, K., Lin, E.C. J. Bacteriol. (1998) [Pubmed]
  10. Involvement of the Escherichia coli O157:H7(pO157) ecf operon and lipid A myristoyl transferase activity in bacterial survival in the bovine gastrointestinal tract and bacterial persistence in farm water troughs. Yoon, J.W., Lim, J.Y., Park, Y.H., Hovde, C.J. Infect. Immun. (2005) [Pubmed]
  11. Map location of the ssd mutation in Escherichia coli K-12. Morris, J.F., Newman, E.B. J. Bacteriol. (1980) [Pubmed]
  12. Environmental regulation of Salmonella typhi invasion-defective mutants. Leclerc, G.J., Tartera, C., Metcalf, E.S. Infect. Immun. (1998) [Pubmed]
  13. Involvement of the Cpx signal transduction pathway of E. coli in biofilm formation. Dorel, C., Vidal, O., Prigent-Combaret, C., Vallet, I., Lejeune, P. FEMS Microbiol. Lett. (1999) [Pubmed]
  14. Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide. Schaller, A., Guo, M., Gisanrin, O., Zhang, Y. FEMS Microbiol. Lett. (2002) [Pubmed]
  15. The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Dong, J., Iuchi, S., Kwan, H.S., Lu, Z., Lin, E.C. Gene (1993) [Pubmed]
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