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Gene Review:

pnuC -

Haemophilus influenzae Rd KW20

Sauer, E. et al., Herbert, M. et al.

Herbert, Sauer, Smethurst, Kraiss, Hilpert, Reidl,

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Disease relevance of pnuC

When E. coli PnuC was expressed in an H. influenzae pnuC mutant, it was able to take up only nicotinamide riboside and not nicotinamide mononucleotide [1].
The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae [2].
We now report on the cellular location, topology, and substrate specificity of PnuC. pnuC of H. influenzae is only distantly related to pnuC of Escherichia coli and Salmonella enterica serovar Typhimurium [1].

High impact information on pnuC

3-Aminopyridine riboside is utilized effectively in a pnuC+ background [1].

References

PnuC and the utilization of the nicotinamide riboside analog 3-aminopyridine in Haemophilus influenzae. Sauer, E., Merdanovic, M., Mortimer, A.P., Bringmann, G., Reidl, J. Antimicrob. Agents Chemother. (2004) [Pubmed]
Nicotinamide ribosyl uptake mutants in Haemophilus influenzae. Herbert, M., Sauer, E., Smethurst, G., Kraiss, A., Hilpert, A.K., Reidl, J. Infect. Immun. (2003) [Pubmed]

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