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Gene Review:

CalHV3gp73 - ORF65

Callitrichine herpesvirus 3

Sun, R. et al., Gao, S.J. et al., Mayama, S. et al., Nealon, K. et al.

Gao, Alsina, Deng, Harrison, Montalvo, Leach, Roodman, Jenson,

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Disease relevance of CalHV3gp73

The transcript of sVCA (ORF65), a late gene whose expression was abolished by Phosphonoacetic acid, an inhibitor of KSHV DNA replication, did not appear until 30 h after induction [1].
In children younger than 12 years of age, antibodies to LANA and the orf65 protein were independently associated with hepatitis B infection (p < 0.005) [2].
Antibodies to KSHV recombinant minor capsid antigen orf65 were found in 81% of patients with multiple myeloma, 22% of control patients with other cancers, and 6% of the blood donors [3].

High impact information on CalHV3gp73

In contrast, the fourth protein, ORF65, lacks significant sequence homology to its structural counterparts from the other subfamilies [4].

References

Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. Sun, R., Lin, S.F., Staskus, K., Gradoville, L., Grogan, E., Haase, A., Miller, G. J. Virol. (1999) [Pubmed]
Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Mayama, S., Cuevas, L.E., Sheldon, J., Omar, O.H., Smith, D.H., Okong, P., Silvel, B., Hart, C.A., Schulz, T.F. Int. J. Cancer (1998) [Pubmed]
Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. Gao, S.J., Alsina, M., Deng, J.H., Harrison, C.R., Montalvo, E.A., Leach, C.T., Roodman, G.D., Jenson, H.B. J. Infect. Dis. (1998) [Pubmed]
Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Nealon, K., Newcomb, W.W., Pray, T.R., Craik, C.S., Brown, J.C., Kedes, D.H. J. Virol. (2001) [Pubmed]

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