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Gene Review

ligA  -  NAD-dependent DNA ligase LigA

Escherichia coli O157:H7 str. EDL933

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Disease relevance of lig

  • Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae [1].
  • The Sma DNA ligase gene was expressed under the control of the T7lac promoter on the pET-22b(+) in Escherichia coli BL21-CodonPlus(DE3)-RIL [2].

High impact information on lig


Analytical, diagnostic and therapeutic context of lig

  • Southern blot analysis indicated the conservation of the lig genes among pathogenic leptospires [3].


  1. Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae. Cheng, C., Shuman, S. Nucleic Acids Res. (1997) [Pubmed]
  2. Cloning and expression of a DNA ligase from the hyperthermophilic archaeon Staphylothermus marinus and properties of the enzyme. Seo, M.S., Kim, Y.J., Choi, J.J., Lee, M.S., Kim, J.H., Lee, J.H., Kwon, S.T. J. Biotechnol. (2007) [Pubmed]
  3. Leptospiral immunoglobulin-like proteins elicit protective immunity. Koizumi, N., Watanabe, H. Vaccine (2004) [Pubmed]
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