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Gene Review:

recF - recombination protein F

Escherichia coli O157:H7 str. EDL933

Yu, W.L. et al., Courcelle, C.T. et al., Fujii, S. et al.

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Disease relevance of recF

Mutations in recF, recO or recR gene abolish induced mutagenesis in E. coli [1].

High impact information on recF

After UV-induced DNA damage in Escherichia coli, RecA and several recF pathway proteins are thought to process arrested replication forks and ensure that replication resumes accurately [2].
The DNA sequences of the genetic environment surrounding bla(SHV-5) were homologous to plasmid p1658/97 from Escherichia coli, containing a truncated recF gene and a truncated deoR gene upstream and downstream from bla(SHV-5), respectively [3].

References

RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis. Fujii, S., Isogawa, A., Fuchs, R.P. EMBO J. (2006) [Pubmed]
Nascent DNA processing by RecJ favors lesion repair over translesion synthesis at arrested replication forks in Escherichia coli. Courcelle, C.T., Chow, K.H., Casey, A., Courcelle, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Genetic association of blaSHV-5 with transposable elements IS26 and IS5 in Klebsiella pneumoniae from Taiwan. Yu, W.L., Chen, S.C., Hung, S.W., Chuang, Y.C., Chung, J.G., Chen, I.C., Wu, L.T. Clin. Microbiol. Infect. (2006) [Pubmed]

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