The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

deoR  -  DNA-binding transcriptional repressor DeoR

Escherichia coli UTI89

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of deoR

  • Large DNA loops resulting from such interactions have been observed in Escherichia coli with the transcription factors deoR [3] and NtrC [4], but such interactions are not, as yet, well understood [1].

High impact information on deoR

  • Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli [2].
  • Repression of the promoters can be achieved either by supplying extra deoR repressor in trans or by introduction of an extra deoR binding site at a position between 224 and 997 bp upstream of the promoter [2].
  • The synthesis of the four enzymes of the deo operon in Escherichia coli is known from in vivo experiments to be subject to a double negative control, exerted by the products of the cytR and deoR genes [3].
  • The DNA sequences of the genetic environment surrounding bla(SHV-5) were homologous to plasmid p1658/97 from Escherichia coli, containing a truncated recF gene and a truncated deoR gene upstream and downstream from bla(SHV-5), respectively [4].

Analytical, diagnostic and therapeutic context of deoR

  • Such loops are easily observed by electron microscopy when the oligomeric deoR repressor is added to a DNA fragment carrying the three genetically defined operators at their chromosomal distances [5].


  1. Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Révet, B., von Wilcken-Bergmann, B., Bessert, H., Barker, A., Müller-Hill, B. Curr. Biol. (1999) [Pubmed]
  2. Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli. Dandanell, G., Hammer, K. EMBO J. (1985) [Pubmed]
  3. Regulation of the deo operon in Escherichia coli: the double negative control of the deo operon by the cytR and deoR repressors in a DNA directed in vitro system. Valentin-Hansen, P., Svenningsen, B.A., Munch-Petersen, A., Hammer-Jespersen, K. Mol. Gen. Genet. (1978) [Pubmed]
  4. Genetic association of blaSHV-5 with transposable elements IS26 and IS5 in Klebsiella pneumoniae from Taiwan. Yu, W.L., Chen, S.C., Hung, S.W., Chuang, Y.C., Chung, J.G., Chen, I.C., Wu, L.T. Clin. Microbiol. Infect. (2006) [Pubmed]
  5. Single and double loop formation when deoR repressor binds to its natural operator sites. Amouyal, M., Mortensen, L., Buc, H., Hammer, K. Cell (1989) [Pubmed]
WikiGenes - Universities