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Gene Review:

recR - gap repair protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0466, JW0461

Mahdi, A.A. et al., Wang, T.C. et al., Liu, Y.H. et al., Hegde, S. et al., Fujii, S. et al.

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Disease relevance of recR

The recR locus of Escherichia coli K-12: molecular cloning, DNA sequencing and identification of the gene product [1].

High impact information on recR

Mutations in recF, recO or recR gene abolish induced mutagenesis in E. coli [2].
The recR gene of Escherichia coli, which is associated with recBC-independent mechanisms of recombination and DNA repair, has been located between dnaZX and htpG on a 6.4 kb EcoRI fragment of DNA that has been cloned and analysed in lambda and plasmid vectors [1].
The second of these two reading frames was identified as recR [1].
In this work, we report that null mutations in recF, recO, or recR greatly reduce UV-radiation mutagenesis (UVM) in an assay for reversion from a Trp- (trpE65) to a Trp+ phenotypes [3].

Biological context of recR

recO and recR mutations delay induction of the SOS response in Escherichia coli [4].

Other interactions of recR

The ability of recA718, recA720, recA730, recA750 and two known recA(Srf) alleles (recA2020 and recA441) to act as suppressors of recF, recR and recO mutations was examined by studying their UV radiation sensitivity in uvrA cells of Escherichia coli [5].

References

The recR locus of Escherichia coli K-12: molecular cloning, DNA sequencing and identification of the gene product. Mahdi, A.A., Lloyd, R.G. Nucleic Acids Res. (1989) [Pubmed]
RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis. Fujii, S., Isogawa, A., Fuchs, R.P. EMBO J. (2006) [Pubmed]
Involvement of recF, recO, and recR genes in UV-radiation mutagenesis of Escherichia coli. Liu, Y.H., Cheng, A.J., Wang, T.C. J. Bacteriol. (1998) [Pubmed]
recO and recR mutations delay induction of the SOS response in Escherichia coli. Hegde, S., Sandler, S.J., Clark, A.J., Madiraju, M.V. Mol. Gen. Genet. (1995) [Pubmed]
Cosuppression of recF, recR and recO mutations by mutant recA alleles in Escherichia coli cells. Wang, T.C., Chang, H.Y., Hung, J.L. Mutat. Res. (1993) [Pubmed]

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