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Gene Review

upp  -  uracil phosphoribosyltransferase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of upp

  • We generated Ax3CAUP-FZ33 (UP-FZ33), which is an Adv-FZ33 derivative vector expressing a therapeutic gene (i.e., Escherichia coli uracil phosphoribosyltransferase), which converts 5-fluorouracil (5-FU) directly to 5-fluoro-UMP [1].

High impact information on upp


  1. Carcinoembryonic antigen-targeted selective gene therapy for gastric cancer through FZ33 fiber-modified adenovirus vectors. Tanaka, T., Huang, J., Hirai, S., Kuroki, M., Kuroki, M., Watanabe, N., Tomihara, K., Kato, K., Hamada, H. Clin. Cancer Res. (2006) [Pubmed]
  2. Transport of adenine, hypoxanthine and uracil into Escherichia coli. Burton, K. Biochem. J. (1977) [Pubmed]
  3. Orientation of the guanine operon of Escherichia coli K-12 by utilizing strains containing guaB-xse and guaB-upp deletions. Vales, L.D., Chase, J.W., Murphy, J.B. J. Bacteriol. (1979) [Pubmed]
  4. Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12. Rasmussen, U.B., Mygind, B., Nygaard, P. Biochim. Biophys. Acta (1986) [Pubmed]
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