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Gene Review:

sdiA - DNA-binding transcriptional activator SdiA

Escherichia coli O157:H7 str. EDL933

García-Lara, J. et al., Wei, Y. et al.

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Disease relevance of sdiA

In this paper, we report that expression of sdiA is itself regulated by a factor that is released into the growth medium by E. coli [1].

High impact information on sdiA

Global impact of sdiA amplification revealed by comprehensive gene expression profiling of Escherichia coli [2].
As expected, increased sdiA dosage led to significantly elevated sdiA and 'ddlB-ftsQAZ-lpxC operon expression [2].
To help us understand this resistance phenotype, genes whose expression was altered by increased sdiA dosage were identified using a DNA microarray-based, comprehensive transcript profiling method [2].
An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli [1].
An effect of conditioned medium on ftsQ2p expression was not seen when the wild-type sdiA gene was disrupted by insertional mutagenesis, indicating that the effect on ftsQ2p expression was secondary to the down-regulation of PsdiA [1].

References

An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli. García-Lara, J., Shang, L.H., Rothfield, L.I. J. Bacteriol. (1996) [Pubmed]
Global impact of sdiA amplification revealed by comprehensive gene expression profiling of Escherichia coli. Wei, Y., Lee, J.M., Smulski, D.R., LaRossa, R.A. J. Bacteriol. (2001) [Pubmed]

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