Disease relevance of ORF1

• Nonstructural Proteins of Respiratory Syncytial Virus Suppress Premature Apoptosis by an NF-{kappa}B-Dependent, Interferon-Independent Mechanism and Facilitate Virus Growth [1].
• Rice grassy stunt tenuivirus nonstructural protein p5 interacts with itself to form oligomeric complexes in vitro and in vivo [2].

High impact information on ORF1

• Two nonstructural cysteine-containing peptides unique for ESV p80 and three specific for Y73 p90 were also identified [3].
• NS-dependent suppression of apoptosis was observed in Vero cells that are naturally devoid of type I interferons (IFN) [1].
• Coincident with NS protein expression, a number of cellular antiapoptotic factors were expressed or activated at early stages, which included NF-kappaB and phosphorylated forms of protein kinases AKT, phosphoinositide-dependent protein kinase, and glycogen synthase kinase [1].
• The second gene in the 3'-to-5' gene order in respiratory syncytial virus (RSV) encodes the nonstructural protein NS2, for which there is no assigned function [4].
• Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction [5].

Biological context of ORF1

• Premature apoptosis triggered by the loss of NS or by apoptosis-promoting drugs caused a severe reduction of RSV growth [1].
• The two major proteins found in plants infected with rice stripe virus (RSV), coat protein and a major nonstructural protein (major NS), were purified and their partial amino acid sequences were determined [6].

References