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Gene Review

FEZ2  -  fasciculation and elongation protein zeta...

Homo sapiens

Synonyms: Fasciculation and elongation protein zeta-2, Zygin II, Zygin-2
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Disease relevance of FEZ2


High impact information on FEZ2

  • In mapping studies we found that the C-terminal regions of FEZ1, and especially its coiled-coil region, are involved in its dimerization, its heterodimerization with FEZ2, and in the interaction with 10 of the identified interacting proteins [1].

Anatomical context of FEZ2

  • Similar to FEZ1, FEZ2 interacted with PKCzeta and induced neurite extension of PC12 cells when coexpressed with a constitutively active mutant of PKCzeta [2].

Other interactions of FEZ2

  • The gene coding for FEZ2, a homologue of FEZ1, has also been reported in rat and human [2].

Analytical, diagnostic and therapeutic context of FEZ2


  1. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. Assmann, E.M., Alborghetti, M.R., Camargo, M.E., Kobarg, J. J. Biol. Chem. (2006) [Pubmed]
  2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita, T., Ikuta, J., Hamada, J., Okajima, T., Tatematsu, K., Tanizawa, K., Kuroda, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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