Disease relevance of FEZ2

• We reported previously that FEZ1 and its paralogue FEZ2 are proteins that interact with NEK1, a protein kinase involved in polycystic kidney disease and DNA repair mechanisms at the G(2)/M phase of the cell cycle [1].

High impact information on FEZ2

• In mapping studies we found that the C-terminal regions of FEZ1, and especially its coiled-coil region, are involved in its dimerization, its heterodimerization with FEZ2, and in the interaction with 10 of the identified interacting proteins [1].

Anatomical context of FEZ2

• Similar to FEZ1, FEZ2 interacted with PKCzeta and induced neurite extension of PC12 cells when coexpressed with a constitutively active mutant of PKCzeta [2].

Other interactions of FEZ2

• The gene coding for FEZ2, a homologue of FEZ1, has also been reported in rat and human [2].

Analytical, diagnostic and therapeutic context of FEZ2

• In this study, we compared mRNA expression of FEZ1 and FEZ2 in adult rat tissues and mouse embryos by Northern blot and in situ hybridization analyses [2].

References