The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FEZ1  -  fasciculation and elongation protein zeta...

Homo sapiens

Synonyms: Fasciculation and elongation protein zeta-1, Zygin I, Zygin-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FEZ1


Psychiatry related information on FEZ1

  • To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts [6].

High impact information on FEZ1

  • (see p. 11 of this issue) report that either binding of the cargo linker c-Jun N-terminal kinase-interacting protein 1 (JIP1) to the light chains (LCs) or binding of fasciculation and elongation protein zeta1 (FEZ1) to the heavy chains (HCs) is insufficient for activation but that activation occurs when both are present simultaneously [7].
  • We identified fasciculation and elongation protein zeta1 (FEZ1) as a binding partner of kinesin heavy chain [8].
  • The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content and contains several regions predicted to form amphipathic helices [9].
  • Although expression of FEZ1 alone had no effect on PC12 cells, coexpression of FEZ1 and constitutively active PKCzeta stimulated the neuronal differentiation of PC12 cells [9].
  • When the constitutively active mutant of PKCzeta was used, FEZ1 was found in the cytoplasm of COS-7 cells [9].

Biological context of FEZ1


Anatomical context of FEZ1


Associations of FEZ1 with chemical compounds

  • By the yeast two-hybrid assay with various deletion mutants of PKC, FEZ1 was shown to interact with the NH2-terminal variable region (V1) of PKCzeta and weakly with that of PKCepsilon [9].
  • Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7muM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs [12].

Physical interactions of FEZ1

  • Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1 (FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study [1].

Other interactions of FEZ1

  • The gene coding for FEZ2, a homologue of FEZ1, has also been reported in rat and human [13].
  • We show that binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for MT binding and motility [8].
  • The confirmed interacting proteins include FEZ1 itself and three transcription controlling proteins (SAP30L, DRAP1, and BAF60a) [11].
  • Recent studies have suggested that DISC1 plays a role in neuronal outgrowth, possibly through reported interactions with the molecules Nudel and FEZ1 [14].

Analytical, diagnostic and therapeutic context of FEZ1

  • FEZ1 is highly expressed in the brain and in situ hybridization analysis of Nbr1 showed that its expression is also regulated in the murine brain during development [10].
  • Northern blot analysis has revealed that FEZ1 mRNA is abundantly expressed in adult rat brain and throughout the developmental stages of mouse embryo [9].
  • Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures [15].
  • Several have proven to be potentially useful clinical targets in the prognosis and therapy of bladder cancer such as staining for p53 and gene therapy strategies such as p53 and fez1 [16].


  1. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Miyoshi, K., Honda, A., Baba, K., Taniguchi, M., Oono, K., Fujita, T., Kuroda, S., Katayama, T., Tohyama, M. Mol. Psychiatry (2003) [Pubmed]
  2. Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Nonaka, D., Fabbri, A., Roz, L., Mariani, L., Vecchione, A., Moore, G.W., Tavecchio, L., Croce, C.M., Sozzi, G. Cancer Res. (2005) [Pubmed]
  3. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T., Nakayama, K.I. J. Biol. Chem. (2004) [Pubmed]
  4. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. Suzuki, T., Okada, Y., Semba, S., Orba, Y., Yamanouchi, S., Endo, S., Tanaka, S., Fujita, T., Kuroda, S., Nagashima, K., Sawa, H. J. Biol. Chem. (2005) [Pubmed]
  5. Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas. Ono, K., Uzawa, K., Nakatsuru, M., Shiiba, M., Mochida, Y., Tada, A., Bukawa, H., Miyakawa, A., Yokoe, H., Tanzawa, H. Int. J. Oncol. (2003) [Pubmed]
  6. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. Yamada, K., Nakamura, K., Minabe, Y., Iwayama-Shigeno, Y., Takao, H., Toyota, T., Hattori, E., Takei, N., Sekine, Y., Suzuki, K., Iwata, Y., Miyoshi, K., Honda, A., Baba, K., Katayama, T., Tohyama, M., Mori, N., Yoshikawa, T. Biol. Psychiatry (2004) [Pubmed]
  7. Jump-starting kinesin. Hackney, D.D. J. Cell Biol. (2007) [Pubmed]
  8. Two binding partners cooperate to activate the molecular motor Kinesin-1. Blasius, T.L., Cai, D., Jih, G.T., Toret, C.P., Verhey, K.J. J. Cell Biol. (2007) [Pubmed]
  9. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda, S., Nakagawa, N., Tokunaga, C., Tatematsu, K., Tanizawa, K. J. Cell Biol. (1999) [Pubmed]
  10. NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. Whitehouse, C., Chambers, J., Howe, K., Cobourne, M., Sharpe, P., Solomon, E. Eur. J. Biochem. (2002) [Pubmed]
  11. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. Assmann, E.M., Alborghetti, M.R., Camargo, M.E., Kobarg, J. J. Biol. Chem. (2006) [Pubmed]
  12. Inhibitors of the FEZ-1 metallo-beta-lactamase. Liénard, B.M., Horsfall, L.E., Galleni, M., Frère, J.M., Schofield, C.J. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  13. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita, T., Ikuta, J., Hamada, J., Okajima, T., Tatematsu, K., Tanizawa, K., Kuroda, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  14. Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Brandon, N.J., Schurov, I., Camargo, L.M., Handford, E.J., Duran-Jimeniz, B., Hunt, P., Millar, J.K., Porteous, D.J., Shearman, M.S., Whiting, P.J. Mol. Cell. Neurosci. (2005) [Pubmed]
  15. Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures. Toyooka, S., Fukuyama, Y., Wistuba, I.I., Tockman, M.S., Minna, J.D., Gazdar, A.F. Clin. Cancer Res. (2002) [Pubmed]
  16. Molecular genetics of bladder cancer: targets for diagnosis and therapy. Baffa, R., Letko, J., McClung, C., LeNoir, J., Vecchione, A., Gomella, L.G. J. Exp. Clin. Cancer Res. (2006) [Pubmed]
WikiGenes - Universities