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Gene Review

PLCH2  -  phospholipase C, eta 2

Homo sapiens

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, KIAA0450, PLC-L4, PLC-eta2, PLCL4, ...
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Disease relevance of PLCH2

  • PLC-eta2-specific antisera recognized one of these splice variants as an approx. 155 kDa species when expressed in COS-7 cells; PLC-eta2 natively expressed in 1321N1 human astrocytoma cells also migrated as an approx. 155 kDa species [1].

High impact information on PLCH2


Analytical, diagnostic and therapeutic context of PLCH2

  • Molecular cloning and characterization of PLC-eta2 [1].
  • RT-PCR (reverse transcriptase-PCR) analyses illustrated expression of PLC-eta2 in human retina and kidney, as well as in mouse brain, eye and lung [1].
  • Sequence analysis of PLC-eta2 revealed the canonical domains of a PLC isoenzyme with an additional long C-terminus that contains a class II PDZ-binding motif [1].


  1. Molecular cloning and characterization of PLC-eta2. Zhou, Y., Wing, M.R., Sondek, J., Harden, T.K. Biochem. J. (2005) [Pubmed]
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