Gene Review:
PLCH2 - phospholipase C, eta 2
Homo sapiens
Synonyms:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, KIAA0450, PLC-L4, PLC-eta2, PLCL4, ...
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Disease relevance of PLCH2
- PLC-eta2-specific antisera recognized one of these splice variants as an approx. 155 kDa species when expressed in COS-7 cells; PLC-eta2 natively expressed in 1321N1 human astrocytoma cells also migrated as an approx. 155 kDa species [1].
High impact information on PLCH2
- Genomic analyses indicated that PLC-eta2 is encoded by 23 exons [1].
- Most of the coding sequence of PLC-eta2 was constructed from two ESTs (expressed sequence tags), which included an overlapping sequence that was confirmed by multiple ESTs and mRNAs [1].
- Co-expression of PLC-eta2 with Gbeta1gamma2 dimers of heterotrimeric G-proteins resulted in marked stimulation of inositol lipid hydrolysis [1].
Analytical, diagnostic and therapeutic context of PLCH2
- Molecular cloning and characterization of PLC-eta2 [1].
- RT-PCR (reverse transcriptase-PCR) analyses illustrated expression of PLC-eta2 in human retina and kidney, as well as in mouse brain, eye and lung [1].
- Sequence analysis of PLC-eta2 revealed the canonical domains of a PLC isoenzyme with an additional long C-terminus that contains a class II PDZ-binding motif [1].
References
- Molecular cloning and characterization of PLC-eta2. Zhou, Y., Wing, M.R., Sondek, J., Harden, T.K. Biochem. J. (2005) [Pubmed]
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