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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCP110  -  centriolar coiled coil protein 110kDa

Homo sapiens

Synonyms: CEP110, CP110, Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa, Cep110, ...
 
 
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High impact information on CP110

  • Both gain- and loss-of-function experiments demonstrate that Plk4 is required--in cooperation with Cdk2, CP110 and Hs-SAS6--for the precise reproduction of centrosomes during the cell cycle [1].
  • We have measured the COP of 108 samples of plasma substitute across selectively permeable membranes which retain molecules greater than 10,000 dalton (COP10) and 50,000 dalton (COP50) the ratio COP50/COP10 providing a potential index of diffusibility of the smaller molecules across capillary membranes [2].
  • In patients with normal capillary permeability both Gelofusine and Dextran 110 are likely to show adequate retention in the circulation with a COP50/COP10 ratio of 0.37 and 0.39 respectively [2].
  • Our data suggest that CP110 is a physiological centrosomal CDK target that promotes centrosome duplication, and its deregulation may contribute to genomic instability [3].
  • Long-term disruption of CP110 phosphorylation leads to unscheduled centrosome separation and overt polyploidy [3].

References

  1. The Polo kinase Plk4 functions in centriole duplication. Habedanck, R., Stierhof, Y.D., Wilkinson, C.J., Nigg, E.A. Nat. Cell Biol. (2005) [Pubmed]
  2. In vitro colloid osmotic pressure of commonly used plasma expanders and substitutes: a study of the diffusibility of colloid molecules. Webb, A.R., Barclay, S.A., Bennett, E.D. Intensive care medicine. (1989) [Pubmed]
  3. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Chen, Z., Indjeian, V.B., McManus, M., Wang, L., Dynlacht, B.D. Dev. Cell (2002) [Pubmed]
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