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Gene Review:

LAPTM4A - lysosomal protein transmembrane 4 alpha

Homo sapiens

Synonyms: Golgi 4-transmembrane-spanning transporter MTP, HUMORF13, KIAA0108, LAPTM4, Lysosomal-associated transmembrane protein 4A, ...

Sufrin, J.R. et al., Liu, J. et al., Liu, X.R. et al.

Liu, Zhou, Zhang, Zhang, Jin, Lin, Rui, Ye,

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High impact information on LAPTM4A

In mammalian cells, MTA undergoes a phosphorolytic cleavage catalyzed by MTA phosphorylase to produce adenine and 5-deoxy-5-(methylthio)ribose-1-phosphate (MTRP) [1].
Adenine is utilized in purine salvage pathways, and MTRP is subsequently recycled to methionine [1].
LAPTM4B showed relatively high homology to LAPTM4A and LAPTM5 in various species [2].
Analysis of the deduced amino acid sequence indicated that it is 38% (88/229) identical to human Golgi 4-transmembrane spanning transporter MTP [3].

References

Methionine recycling pathways and antimalarial drug design. Sufrin, J.R., Meshnick, S.R., Spiess, A.J., Garofalo-Hannan, J., Pan, X.Q., Bacchi, C.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. Liu, X.R., Zhou, R.L., Zhang, Q.Y., Zhang, Y., Jin, Y.Y., Lin, M., Rui, J.A., Ye, D.X. World J. Gastroenterol. (2004) [Pubmed]
Biological function of a novel gene overexpressed in human hepatocellular carcinoma. Liu, J., Zhou, R., Zhang, N., Rui, J., Jin, C. Chin. Med. J. (2000) [Pubmed]

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