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Gene Review:

LAPTM4B - lysosomal protein transmembrane 4 beta

Homo sapiens

Synonyms: LAPTM4beta, LC27, Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta, PSEC0001

Liu, X.R. et al., Shao, G.Z. et al., Morris, D.G. et al., Peng, C. et al.

Liu, Zhou, Zhang, Zhang, Jin, Lin, Rui, Ye,

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Disease relevance of LAPTM4B

Lysosomal-associated protein transmembrane- 4-beta (LAPTM4B), a novel gene upregulated in hepatocellular carcinoma, was significantly over-expressed in adrenocorticotrophin (ACTH)-secreting adenomas and non-functioning pituitary adenomas (NFPAs) [1].

High impact information on LAPTM4B

Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma [2].
LAPTM4B was also overexpressed in many HCC-derived cell lines [2].
Expressions of LAPTM4B in HCC tissues and various cell lines were detected using polyclonal antibodies and Western blot [3].
METHODS: Primary structure and fundamental characteristics of LAPTM4B protein were analysed with bioinformatics [3].

Associations of LAPTM4B with chemical compounds

AIM: To analyze the structure and expressions of the protein encoded by an HCC-associated novel gene, lysosome-associated protein transmembrane 4 beta (LAPTM4B) [3].

Analytical, diagnostic and therapeutic context of LAPTM4B

Northern blot showed that the LAPTM4B mRNAs were remarkably upregulated in HCC (87.3%) and correlated inversely with differentiation status [2].
METHODS: The 297 bp 5' end of LAPTM4B cDNA was obtained by PCR and inserted into prokaryotic expression vector pGEX-KG [4].

References

Differential gene expression in pituitary adenomas by oligonucleotide array analysis. Morris, D.G., Musat, M., Czirják, S., Hanzély, Z., Lillington, D.M., Korbonits, M., Grossman, A.B. Eur. J. Endocrinol. (2005) [Pubmed]
Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Shao, G.Z., Zhou, R.L., Zhang, Q.Y., Zhang, Y., Liu, J.J., Rui, J.A., Wei, X., Ye, D.X. Oncogene (2003) [Pubmed]
Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. Liu, X.R., Zhou, R.L., Zhang, Q.Y., Zhang, Y., Jin, Y.Y., Lin, M., Rui, J.A., Ye, D.X. World J. Gastroenterol. (2004) [Pubmed]
Expression of lysosome-associated protein transmembrane 4B-35 in cancer and its correlation with the differentiation status of hepatocellular carcinoma. Peng, C., Zhou, R.L., Shao, G.Z., Rui, J.A., Wang, S.B., Lin, M., Zhang, S., Gao, Z.F. World J. Gastroenterol. (2005) [Pubmed]

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