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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LAPTM5  -  lysosomal protein transmembrane 5

Homo sapiens

Synonyms: KIAA0085, Lysosomal-associated multitransmembrane protein 5, Lysosomal-associated transmembrane protein 5, Retinoic acid-inducible E3 protein
 
 
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Disease relevance of LAPTM5

  • Interestingly, Clast6/E3/LAPTM5 was expressed at high levels in malignant B lymphomas [1].
 

High impact information on LAPTM5

  • These results demonstrate a novel mechanism by which the ubiquitin-ligase Nedd4, via interactions with GGA3 and cargo (LAPTM5), regulates cargo trafficking to the lysosome without requiring cargo ubiquitination [2].
  • Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination [2].
  • The gene, provisionally named LAPTM5, maps to chromosome 1p34 [3].
  • LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells [3].
  • Clast6/E3/LAPTM5 is abundantly expressed in resting mature B cells but is rapidly and transiently repressed by treatment with CD40 ligand, a T helper signal that induces B cell activation [1].
 

Anatomical context of LAPTM5

  • Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas [1].
 

Other interactions of LAPTM5

References

  1. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. Seimiya, M., O-Wang, J., Bahar, R., Kawamura, K., Wang, Y., Saisho, H., Tagawa, M. Int. J. Oncol. (2003) [Pubmed]
  2. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. Pak, Y., Glowacka, W.K., Bruce, M.C., Pham, N., Rotin, D. J. Cell Biol. (2006) [Pubmed]
  3. LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Adra, C.N., Zhu, S., Ko, J.L., Guillemot, J.C., Cuervo, A.M., Kobayashi, H., Horiuchi, T., Lelias, J.M., Rowley, J.D., Lim, B. Genomics (1996) [Pubmed]
  4. Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. Liu, X.R., Zhou, R.L., Zhang, Q.Y., Zhang, Y., Jin, Y.Y., Lin, M., Rui, J.A., Ye, D.X. World J. Gastroenterol. (2004) [Pubmed]
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