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Gene Review

RNF40  -  ring finger protein 40, E3 ubiquitin...

Homo sapiens

Synonyms: 95 kDa retinoblastoma-associated protein, BRE1-B, BRE1B, E3 ubiquitin-protein ligase BRE1B, KIAA0661, ...

Disease relevance of RNF40


High impact information on RNF40

  • RNF40 functions together with RNF20, where both are essential for histone H2B monoubiquitination [2] [3].
  • RNF20 and RNF40 form a complex with Rad6A/UBE2A to control histone H2B monoubiquitination [3].
  • RH mapping results showed that RBP95 is mapped to chromosome region 16p11.2-11 [1].
  • RBP95 was located in the nucleus with a special pattern when expressed as a GFP fusion in HeLa cells [1].
  • All these findings suggested that RBP95, a new member of Rb1-associated protein, may function as a regulation factor in the process of RNA polymerase II-mediated transcription and/or transcriptional processing [1].
  • RNF40 is a RING finger ubiquitin ligase that complexes with RNF20 [4] [5].
  • RNF40 and RNF20 regulation the expression of Hox genes as well as autoinduction of the retinoic acid receptor gene [4] [5].
  • RNF40 and RNF20 appear to be the functional orthologues of the yeast H2B ubiquitin ligase Bre1.
  • RNF40 and RNF20 are required for homologous recombination DNA repair [6] [7] [8].

Analytical, diagnostic and therapeutic context of RNF40

  • 1. Sequence analysis indicated that RBP95 contains a conserved Rb1-binding motif LXCXE [1]. An LXCXE sequence is also found in the mouse Rnf40 protein but is not present in either mouse or human RNF20 proteins.



  1. RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein. Wen, H., Ao, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. Pirngruber, J., Shchebet, A., Schreiber, L., Shema, E., Minsky, N., Chapman, R.D., Eick, D., Aylon, Y., Oren, M., Johnsen, S.A. EMBO. Rep. (2009) [Pubmed]
  3. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Kim, J., Guermah, M., McGinty, R.K., Lee, J.S., Tang, Z., Milne, T.A., Shilatifard, A., Muir, T.W., Roeder, R.G. Cell. (2009) [Pubmed]
  4. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., Reinberg, D. Cell. (2006) [Pubmed]
  5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Zhu, B., Zheng, Y., Pham, A.D., Mandal, S.S., Erdjument-Bromage, H., Tempst, P., Reinberg, D. Mol. Cell. (2005) [Pubmed]
  6. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Moyal, L., Lerenthal, Y., Gana-Weisz, M., Mass, G., So, S., Wang, S.Y., Eppink, B., Chung, Y.M., Shalev, G., Shema, E., Shkedy, D., Smorodinsky, N.I., van Vliet, N., Kuster, B., Mann, M., Ciechanover, A., Dahm-Daphi, J., Kanaar, R., Hu, M.C., Chen, D.J., Oren, M., Shiloh, Y. Mol. Cell. (2011) [Pubmed]
  7. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Chernikova, S.B., Dorth, J.A., Razorenova, O.V., Game, J.C., Brown, J.M. Radiat. Res. (2010) [Pubmed]
  8. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Nakamura, K., Kato, A., Kobayashi, J., Yanagihara, H., Sakamoto, S., Oliveira, D.V., Shimada, M., Tauchi, H., Suzuki, H., Tashiro, S., Zou, L., Komatsu, K. Mol. Cell. (2011) [Pubmed]
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