Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

bla - beta-lactamase

Xanthomonas campestris pv. campestris str. ATCC 33913

Weng, S.F. et al., Weng, S.F. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of bla

Constitutive expression of a chromosomal class A (BJM group 2) beta-lactamase in Xanthomonas campestris [1].

High impact information on bla

It runs divergently from bla(XCC-1) with a 100-bp intergenic region (IG) containing partially overlapped promoters with structural features typical of the bla-ampR IG [1].
An ampR1 homologue was detected by Southern hybridization in the ampicillin-resistant Xanthomonas strains, which appear to express beta-lactamase constitutively [1].
The Xanthomonas campestris pv. campestris 11 chromosome encodes a periplasmic beta-lactamase of 30 kDa [2].

Biological context of bla

Four bla genes and two ampR genes are present in the fully sequenced X. campestris pv. campestris ATCC 33913 genome, with XCC3039 and XCC3040 considered the analogues of bla(XCC-1) and ampR1, respectively [1].

Analytical, diagnostic and therapeutic context of bla

Results of insertional mutation, complementation tests, and beta-lactamase assays suggested that expression of bla(XCC-1) was constitutive and dependent on AmpR1 [1].

References

Constitutive expression of a chromosomal class A (BJM group 2) beta-lactamase in Xanthomonas campestris. Weng, S.F., Lin, J.W., Chen, C.H., Chen, Y.Y., Tseng, Y.H., Tseng, Y.H. Antimicrob. Agents Chemother. (2004) [Pubmed]
Identification of a novel beta-lactamase produced by Xanthomonas campestris, a phytopathogenic bacterium. Weng, S.F., Chen, C.Y., Lee, Y.S., Lin, J.W., Tseng, Y.H. Antimicrob. Agents Chemother. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.