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MeSH Review

Bacteriophage P22

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Disease relevance of Bacteriophage P22

  • Moreover, the RNA-binding, anti-terminator N proteins of lambda, phi21 and P22 phages show sequence similarities with HIV Nef at the Arg-rich motif [1].

High impact information on Bacteriophage P22

  • Proteins with the parallel beta helix fold include three pectate lyases and the tailspike protein from P22 phage [2].
  • These results are discussed in terms of a model in which Abc2 converts the RecBCD exonuclease for use in the P22 phage recombination pathway [3].
  • Three bacterial pectate lyases, a pectin lyase from Aspergillus niger, the structures of rhamnogalacturonase A from Aspergillus aculeatus, RGase A, and the P22-phage tailspike protein, TSP, display the right-handed parallel beta-helix architecture first seen in pectate lyase [4].
  • The effect of a recipient recD mutation was eliminated if the donor P22 phage expressed its Abc (anti-RecBC) function [5].
  • A hybrid P22 phage, in which the T7 18.5 gene replaces the P22 gene 15, exhibits the plating properties of wild-type P22, strongly suggesting that the two genes have similar functions [6].

Chemical compound and disease context of Bacteriophage P22

  • Eclipse of P22 phage particles to whole bacteria was likewise uninfluenced by the cation concentration in the reaction mixture, but eclipse by isolated receptor containing LPS required cations [7].

Gene context of Bacteriophage P22

  • The identity of the cloned Isi1 gene, as a functional rfaF homologue, was confirmed by the complementation of a S. typhimurium rfaF mutant using a P22 phage sensitivity test [8].


  1. The N-terminal Arg-rich region of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef is involved in RNA binding. Echarri, A., González, M.E., Carrasco, L. Eur. J. Biochem. (1997) [Pubmed]
  2. Protein motifs. 3. The parallel beta helix and other coiled folds. Yoder, M.D., Jurnak, F. FASEB J. (1995) [Pubmed]
  3. Bacteriophage P22 Abc2 protein binds to RecC increases the 5' strand nicking activity of RecBCD and together with lambda bet, promotes Chi-independent recombination. Murphy, K.C. J. Mol. Biol. (2000) [Pubmed]
  4. Structure and evolution of parallel beta-helix proteins. Jenkins, J., Mayans, O., Pickersgill, R. J. Struct. Biol. (1998) [Pubmed]
  5. Salmonella recD mutations increase recombination in a short sequence transduction assay. Miesel, L., Roth, J.R. J. Bacteriol. (1994) [Pubmed]
  6. Nucleotide sequence of the bacteriophage P22 gene 19 to 3 region: identification of a new gene required for lysis. Casjens, S., Eppler, K., Parr, R., Poteete, A.R. Virology (1989) [Pubmed]
  7. Adsorption of phage P22 to Salmonella typhimurium. Eriksson, U., Lindberg, A.A. J. Gen. Virol. (1977) [Pubmed]
  8. Cloning and molecular analysis of the Isi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells. Jennings, M.P., Bisercic, M., Dunn, K.L., Virji, M., Martin, A., Wilks, K.E., Richards, J.C., Moxon, E.R. Microb. Pathog. (1995) [Pubmed]
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