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MeSH Review


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Disease relevance of Neurothekeoma


High impact information on Neurothekeoma

  • Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma [2].
  • We studied a series of 11 cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100 [2].
  • In contrast, immunoreactivity to S-100 protein is only positive in 3 of 12 cases of cellular neurothekeoma [3].
  • PGP9.5: a marker for cellular neurothekeoma [3].
  • All cellular neurothekeomas failed to express S-100 protein, whereas the three myxomatous types were strongly positive for this marker [4].

Chemical compound and disease context of Neurothekeoma


Gene context of Neurothekeoma

  • These results, such as the concomitant expressions of PGP9.5/S-100A6 and PG-M1/CD68 (KP-1), support the theory of multiple differentiation in cellular neurothekeomas [6].
  • RESULTS: All 11 neurothekeoma cases were positive for S100A6 protein (four cases, weak/1+; seven cases, strong/2+), corresponding to 100% sensitivity [5].
  • The significance of the expression of CD10 in this cellular neurothekeoma is unclear [6].


  1. Comparative immunoreactivity of CD-68 and HMB-45 in malignant melanoma, neural tumors and nevi. Shah, I.A., Gani, O.S., Wheler, L. Pathol. Res. Pract. (1997) [Pubmed]
  2. Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. Page, R.N., King, R., Mihm, M.C., Googe, P.B. Mod. Pathol. (2004) [Pubmed]
  3. PGP9.5: a marker for cellular neurothekeoma. Wang, A.R., May, D., Bourne, P., Scott, G. Am. J. Surg. Pathol. (1999) [Pubmed]
  4. Studies on the cellular origin of neurothekeoma: clinical, light microscopic, immunohistochemical, and ultrastructural observations. Barnhill, R.L., Dickersin, G.R., Nickeleit, V., Bhan, A.K., Muhlbauer, J.E., Phillips, M.E., Mihm, M.C. J. Am. Acad. Dermatol. (1991) [Pubmed]
  5. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. Fullen, D.R., Lowe, L., Su, L.D. J. Cutan. Pathol. (2003) [Pubmed]
  6. Cellular neurothekeoma with histiocytic differentiation. Misago, N., Satoh, T., Narisawa, Y. J. Cutan. Pathol. (2004) [Pubmed]
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