Gene Review:
S100B - S100 calcium binding protein B
Homo sapiens
Synonyms:
NEF, Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100, ...
Diefenbacher,
Eikelenboom,
Baudier,
Akama,
Arolt,
Mori,
Yammani,
Im,
Ponath,
Chapman,
McNutt,
Zimmer,
Mbele,
Schick,
Mangin,
Cuzner,
Thompson,
Frühauf,
Abdul-Khaliq,
Petzold,
Fullen,
Tan,
Schroeter,
Chen,
Uitdehaag,
Yan,
Hetzel,
Wallquist,
Zelano,
Polman,
Tateishi,
Giovannoni,
Griffin,
Asano,
Peskind,
Raskind,
Carlson,
Assard,
Keir,
Kuwano,
Cullheim,
Hailer,
Gveric,
Blasig,
Glaser,
Finnerty,
Reed,
Chessher,
Van Eldik,
Town,
Höhne,
Cole,
Loeser,
Deloulme,
Lazeron,
Landar,
Bursch,
Rothermundt,
Caddell,
- Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Fernandez-Fernandez, M.R., Veprintsev, D.B., Fersht, A.R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells. Lin, J., Yang, Q., Yan, Z., Markowitz, J., Wilder, P.T., Carrier, F., Weber, D.J. J. Biol. Chem. (2004)
- Inhibition of p53 transcriptional activity by the S100B calcium-binding protein. Lin, J., Blake, M., Tang, C., Zimmer, D., Rustandi, R.R., Weber, D.J., Carrier, F. J. Biol. Chem. (2001)
- Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Petzold, A., Eikelenboom, M.J., Gveric, D., Keir, G., Chapman, M., Lazeron, R.H., Cuzner, M.L., Polman, C.H., Uitdehaag, B.M., Thompson, E.J., Giovannoni, G. Brain (2002)
- The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. Mbele, G.O., Deloulme, J.C., Gentil, B.J., Delphin, C., Ferro, M., Garin, J., Takahashi, M., Baudier, J. J. Biol. Chem. (2002)
- Enteric glial-derived S100B protein stimulates nitric oxide production in celiac disease. Esposito, G., Cirillo, C., Sarnelli, G., De Filippis, D., D'Armiento, F.P., Rocco, A., Nardone, G., Petruzzelli, R., Grosso, M., Izzo, P., Iuvone, T., Cuomo, R. Gastroenterology (2007)
- S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia. Rothermundt, M., Ponath, G., Glaser, T., Hetzel, G., Arolt, V. Neuropsychopharmacology (2004)
- Developmental changes in S100B content in brain tissue, cerebrospinal fluid, and astrocyte cultures of rats. Tramontina, F., Conte, S., Gonçalves, D., Gottfried, C., Portela, L.V., Vinade, L., Salbego, C., Gonçalves, C.A. Cell. Mol. Neurobiol. (2002)
- Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Peskind, E.R., Griffin, W.S., Akama, K.T., Raskind, M.A., Van Eldik, L.J. Neurochem. Int. (2001)
- Serum S100B is increased during early treatment with antipsychotics and in deficit schizophrenia. Schroeter, M.L., Abdul-Khaliq, H., Frühauf, S., Höhne, R., Schick, G., Diefenbacher, A., Blasig, I.E. Schizophr. Res. (2003)
- S100B is increased in mood disorders and may be reduced by antidepressive treatment. Schroeter, M.L., Abdul-Khaliq, H., Diefenbacher, A., Blasig, I.E. Neuroreport (2002)
- Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. Allore, R., O'Hanlon, D., Price, R., Neilson, K., Willard, H.F., Cox, D.R., Marks, A., Dunn, R.J. Science (1988)
- Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene. Lindemann, D., Wilhelm, R., Renard, P., Althage, A., Zinkernagel, R., Mous, J. J. Exp. Med. (1994)
- Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis. Hadida, F., Parrot, A., Kieny, M.P., Sadat-Sowti, B., Mayaud, C., Debre, P., Autran, B. J. Clin. Invest. (1992)
- The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. Gentil, B.J., Delphin, C., Mbele, G.O., Deloulme, J.C., Ferro, M., Garin, J., Baudier, J. J. Biol. Chem. (2001)
- S100A6 preferentially labels type C nevus cells and nevic corpuscles: additional support for Schwannian differentiation of intradermal nevi. Fullen, D.R., Reed, J.A., Finnerty, B., McNutt, N.S. J. Cutan. Pathol. (2001)
- Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype. Barsky, S.H., Sternlicht, M.D., Safarians, S., Nguyen, M., Chin, K., Stewart, S.D., Hiti, A.L., Gray, J.W. Oncogene (1997)
- Amyotrophic lateral sclerosis: disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum. Süssmuth, S.D., Tumani, H., Ecker, D., Ludolph, A.C. Neurosci. Lett. (2003)
- Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes. Ding, Y., Kantarci, A., Hasturk, H., Trackman, P.C., Malabanan, A., Van Dyke, T.E. J. Leukoc. Biol. (2007)
- No significant effect of monosomy for distal 21q22.3 on the Down syndrome phenotype in "mirror" duplications of chromosome 21. Pangalos, C., Théophile, D., Sinet, P.M., Marks, A., Stamboulieh-Abazis, D., Chettouh, Z., Prieur, M., Verellen, C., Rethoré, M.O., Lejeune, J. Am. J. Hum. Genet. (1992)
- Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries. Yaspo, M.L., Gellen, L., Mott, R., Korn, B., Nizetic, D., Poustka, A.M., Lehrach, H. Hum. Mol. Genet. (1995)
- Specificity and Zn2+ enhancement of the S100B binding epitope TRTK-12. Barber, K.R., McClintock, K.A., Jamieson, G.A., Dimlich, R.V., Shaw, G.S. J. Biol. Chem. (1999)
- Human S100B protein interacts with the Escherichia coli division protein FtsZ in a calcium-sensitive manner. Ferguson, P.L., Shaw, G.S. J. Biol. Chem. (2004)
- Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Wainwright, M.S., Craft, J.M., Griffin, W.S., Marks, A., Pineda, J., Padgett, K.R., Van Eldik, L.J. Ann. Neurol. (2004)
- A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. McClintock, K.A., Shaw, G.S. J. Biol. Chem. (2003)
- Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Loeser, R.F., Yammani, R.R., Carlson, C.S., Chen, H., Cole, A., Im, H.J., Bursch, L.S., Yan, S.D. Arthritis Rheum. (2005)
- Calcium-dependent interaction of S100B with the C-terminal domain of the tumor suppressor p53. Delphin, C., Ronjat, M., Deloulme, J.C., Garin, G., Debussche, L., Higashimoto, Y., Sakaguchi, K., Baudier, J. J. Biol. Chem. (1999)
- Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. Mori, T., Town, T., Tan, J., Tateishi, N., Asano, T. J. Cereb. Blood Flow Metab. (2005)
- The C-terminus and linker region of S100B exert dual control on protein-protein interactions with TRTK-12. McClintock, K.A., Van Eldik, L.J., Shaw, G.S. Biochemistry (2002)
- S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Deloulme, J.C., Assard, N., Mbele, G.O., Mangin, C., Kuwano, R., Baudier, J. J. Biol. Chem. (2000)
- Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Wilder, P.T., Lin, J., Bair, C.L., Charpentier, T.H., Yang, D., Liriano, M., Varney, K.M., Lee, A., Oppenheim, A.B., Adhya, S., Carrier, F., Weber, D.J. Biochim. Biophys. Acta (2006)
- The three-dimensional structure of human S100A12. Moroz, O.V., Antson, A.A., Murshudov, G.N., Maitland, N.J., Dodson, G.G., Wilson, K.S., Skibshøj, I., Lukanidin, E.M., Bronstein, I.B. Acta Crystallogr. D Biol. Crystallogr. (2001)
- S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains. Leclerc, E., Fritz, G., Weibel, M., Heizmann, C.W., Galichet, A. J. Biol. Chem. (2007)
- Expression of nectin-1, nectin-3, N-cadherin, and NCAM in spinal motoneurons after sciatic nerve transection. Zelano, J., Wallquist, W., Hailer, N.P., Cullheim, S. Exp. Neurol. (2006)
- S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microglia. Reali, C., Scintu, F., Pillai, R., Donato, R., Michetti, F., Sogos, V. J. Neurosci. Res. (2005)
- Nomen est Omen: do antidepressants increase p11 or S100A10? Manev, H., Manev, R. Journal of biomedical discovery and collaboration [electronic resource]. (2006)
- Identification of an S100A1/S100B target protein: phosphoglucomutase. Landar, A., Caddell, G., Chessher, J., Zimmer, D.B. Cell Calcium (1996)
- Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins. Camby, I., Nagy, N., Lopes, M.B., Schäfer, B.W., Maurage, C.A., Ruchoux, M.M., Murmann, P., Pochet, R., Heizmann, C.W., Brotchi, J., Salmon, I., Kiss, R., Decaestecker, C. Brain Pathol. (1999)
- Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. Yang, Q., O'Hanlon, D., Heizmann, C.W., Marks, A. Exp. Cell Res. (1999)