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MeSH Review

Nerve Sheath Neoplasms

 
 
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Disease relevance of Nerve Sheath Neoplasms

 

Psychiatry related information on Nerve Sheath Neoplasms

 

High impact information on Nerve Sheath Neoplasms

 

Chemical compound and disease context of Nerve Sheath Neoplasms

 

Biological context of Nerve Sheath Neoplasms

  • In addition to providing a model for studying the molecular pathogenic pathways of malignant peripheral nerve sheath tumors, these mutant zebrafish lines provide a unique platform for modifier screens to identify genetic mutations or small molecules that affect tp53-related pathways, including apoptosis, cell-cycle delay, and tumor suppression [8].
  • Collaborative research should be promoted with the aim of harnessing advances in molecular genetics to develop targeted therapies for MPNST in people with NF1 [2].
  • Methylation analysis and mutation analysis of CDKN2A/p16 in MPNSTs did not reveal any abnormalities [17].
  • These phenotypes were correlated with proliferative index, as assessed by Ki-67, as well as clinicopathological parameters of poor outcome. p53 nuclear overexpression was found in 10 of 35 (29%) MPNSTs, and it was lacking in NFs (P = 0.02) [18].
  • A deviation from the disomic status of chromosome 17 was observed in two of the MPNST from NF1 patients [19].
 

Anatomical context of Nerve Sheath Neoplasms

 

Gene context of Nerve Sheath Neoplasms

 

Analytical, diagnostic and therapeutic context of Nerve Sheath Neoplasms

References

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  2. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Ferner, R.E., Gutmann, D.H. Cancer Res. (2002) [Pubmed]
  3. Notch and Schwann cell transformation. Li, Y., Rao, P.K., Wen, R., Song, Y., Muir, D., Wallace, P., van Horne, S.J., Tennekoon, G.I., Kadesch, T. Oncogene (2004) [Pubmed]
  4. Expression and function of somatostatin receptors in peripheral nerve sheath tumors. Mawrin, C., Schulz, S., Hellwig-Patyk, A., Kirches, E., Roessner, A., Lendeckel, U., Firsching, R., Vorwerk, C.K., Keilhoff, G., Dietzmann, K., Grimm, K., Lindberg, G., Gutmann, D.H., Scheithauer, B.W., Perry, A. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
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  8. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Berghmans, S., Murphey, R.D., Wienholds, E., Neuberg, D., Kutok, J.L., Fletcher, C.D., Morris, J.P., Liu, T.X., Schulte-Merker, S., Kanki, J.P., Plasterk, R., Zon, L.I., Look, A.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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  17. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Nielsen, G.P., Stemmer-Rachamimov, A.O., Ino, Y., Moller, M.B., Rosenberg, A.E., Louis, D.N. Am. J. Pathol. (1999) [Pubmed]
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