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MeSH Review:

Osteochondromatosis

Kilpatrick, S.E. et al., Chen, W.C. et al., Chan, W.L. et al., Ali, M.M. et al.

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Disease relevance of Osteochondromatosis

Multiple osteochondromatosis, also known as hereditary multiple exostoses (HME), is an inherited autosomal dominant disorder characterized by the presence of multiple exostoses on the long bones [1].

High impact information on Osteochondromatosis

Clinical Image: acute gout in a young man with osteochondromatosis [2].
Tenosynovial osteochondromatosis of both flexor and extensor tendons [3].

Biological context of Osteochondromatosis

Multiple osteochondromatosis (MOS) is a familial disorder of autosomal dominant transmission characterized by the development of multiple exostoses and often derangements of epiphyseal cartilage, sometimes resulting in long bone growth retardation [4].

References

Three novel EXT1 and EXT2 gene mutations in Taiwanese patients with multiple exostoses. Chen, W.C., Chi, C.H., Chuang, C.C., Jou, I.M. J. Formos. Med. Assoc. (2006) [Pubmed]
Clinical Image: acute gout in a young man with osteochondromatosis. Ali, M.M., Meyer, C. Arthritis Rheum. (1999) [Pubmed]
Tenosynovial osteochondromatosis of both flexor and extensor tendons. Chan, W.L., Hung, L.K., Griffith, J.F., Louis, T.C., Ho, P.C. Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand. (2004) [Pubmed]
Dedifferentiated chondrosarcoma in patients with multiple osteochondromatosis: report of a case and review of the literature. Kilpatrick, S.E., Pike, E.J., Ward, W.G., Pope, T.L. Skeletal radiology. (1997) [Pubmed]

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