Disease relevance of Spinal Curvatures

• In contrast, double mutant mice (mdx/utrn(-/-)), deficient for both dystrophin and utrophin die by approximately 3 months and suffer from severe muscle weakness, growth retardation, and severe spinal curvature [1].
• Both arthrogryposis and spinal curvature were produced and were similar to the defects produced by the piperidine alkaloid coniine [2].

High impact information on Spinal Curvatures

• Decreasing expression of Dkk1 results in hemivertebral fusions in progressively more anterior positions, with severity increasing from tail kinks to spinal curvature [3].
• A two-level midcervical osteotomy performed at the level of maximum spinal curvature in ankylosing spondylitis enables complete correction of severe fixed flexion deformity in a single procedure [4].
• Other sublethal effects were observed in surviving larvae and included spastic movements with or without ability to respond to stimulus (>/=6.3 microg cypermethrin/L), spinal curvatures, and delayed or absence of swim bladder inflation (>/=12.5 microg cypermethrin/L) [5].
• Patient 2 developed a rigid scoliotic curve and, despite neurological improvement with levodopa, the spinal curvature remained unresponsive necessitating surgical correction [6].
• Accurate noninvasive measurements of spinal curvature are crucial in planning treatment and assessing curve progression in adolescent idiopathic scoliosis [7].

Chemical compound and disease context of Spinal Curvatures

• CONCLUSIONS: Careful attention to postoperative changes in the spinal curvature is needed when ELAP is performed, especially if surgery involves C2 [8].
• Moreover, in the test tank of diazinon, fenitrothion and BPMC, the appearance of deformed fish with spinal curvature of back bone came out at the rate of 10 to 30% [9].

Gene context of Spinal Curvatures

• Our case illustrates that dopa-responsive dystonia can manifest spinal curvature as the major symptom and warrants its inclusion in the differential diagnoses of idiopathic kyphoscoliosis [10].
• Those with XLH show systemic signs of the disease, such as growth retardation, limb deformity, and spinal curvature disorders; however, these symptoms are more severe in the patient than in the others [11].

Analytical, diagnostic and therapeutic context of Spinal Curvatures

• Observer variation in assessing spinal curvature and skeletal development in adolescent idiopathic scoliosis [12].

References