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Disease relevance of Osteotomy


High impact information on Osteotomy

  • During pamidronate treatment, older age (OR per year of age, 1.25; 95% CI, 1.06-1.47) and osteotomy of the tibia (OR, 3.51; 95% CI, 1.57-7.82) were independent predictors of delayed healing [6].
  • After osteotomies, delayed healing was more frequent when pamidronate had been started before surgery (OR, 7.29; 95% CI, 2.62-20.3), and this effect persisted after adjustment for multiple confounders [6].
  • Recombinant human bone morphogenetic protein-2 enhances osteotomy healing in glucocorticoid-treated rabbits [7].
  • The objectives of this study were to evaluate the effect of chronic prednisolone treatment on osteotomy healing in rabbits and to determine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) would enhance healing in the presence of chronic glucocorticoid therapy [7].
  • By 4 days after osteotomy, BMP-2 and BMP-4 mRNAs were detected in chondrogenic precursor cells in the subperiosteal immature callus [8].

Chemical compound and disease context of Osteotomy


Biological context of Osteotomy


Anatomical context of Osteotomy

  • We used latex injection and a modified Spalteholz technique in cadaveric specimens to demonstrate the effect of the chevron osteotomy, with and without lateral capsular release, on the vascular supply to the first metatarsal head [17].
  • However, shortening femoral osteotomy and transposition of the greater trochanter, adductor and flexor tenotomies, and modification of the femoral stem were frequently needed [18].
  • METHODS: Both an osteotomy and osteoclasis were used to create a model of an intra-articular fracture of the distal part of the radius (AO type C2) with dorsal bone loss in seven pairs of fresh-frozen upper extremities [19].
  • Two self-reinforced poly(desamino tyrosyl-tyrosine ethyl ester carbonate), poly(DTE carbonate) or self-reinforced poly(DTE carbonate)/bioactive glass rods, (2 mm by 40 mm) were implanted into the dorsal subcutaneous tissue and osteotomies of the distal femur were fixed with these rods (2 mm by 26 mm) in 36 rabbits [20].
  • In the coronal plane, the average arc of motion of the subtalar joint decreased from 17.2 +/- 3.3 degrees before the osteotomy to 11.7 +/- 2.9 degrees after the osteotomy and removal of the wedge [21].

Associations of Osteotomy with chemical compounds

  • Consecutive patients undergoing knee arthroplasty or tibial osteotomy at four participating hospitals received either enoxaparin, 30 mg subcutaneously every 12 h (n = 66) or an identical-appearing placebo (n = 65) [22].
  • Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats [23].
  • They included 21 interventions, such as paracetamol, NSAIDs, symptomatic slow acting disease modifying drugs, opioids, intra-articular steroids, non-pharmacological treatment, total hip replacement, osteotomy, and two general propositions [24].
  • The width of the buttress plate along the anteromedial tibial cortex was 2 to 3 mm less than the computed coronal valgus posteromedial osteotomy gap to achieve tibiofemoral valgus correction [25].
  • Use of the porous hydroxyapatite wedges resulted in no collapse or subsidence at the osteotomy site [26].

Gene context of Osteotomy

  • We performed a prospective, randomised double-blind study in 24 patients undergoing high tibial osteotomy to evaluate the effectiveness of human recombinant osteogenic protein (OP-1) on a collagen type-I carrier in a critically-sized fibular defect [27].
  • In vivo results: Continuous application of 1 and 10 micrograms natural TGF-beta to a plated tibial osteotomy in rabbits increased mechanical bending strength and callus formation at 6 weeks observation [28].
  • In conclusion, the local application of IGF-I and TGF-beta1 from a biodegradable coating enhances the osteotomy healing as shown in the biomechanical testing and the histomorphometry [23].
  • The treatment of cervical fixed flexion deformity in ankylosing spondylitis presents a challenging problem that is traditionally managed by a corrective cervicothoracic osteotomy [29].
  • A mini-osmotic pump delivered to the osteotomy gap either recombinant human vascular endothelial growth factor (VEGF), VEGF-inhibitor, or vehicle alone during the latency and distraction phase [30].

Analytical, diagnostic and therapeutic context of Osteotomy


  1. The failed complete repair of bladder exstrophy: insights and outcomes. Gearhart, J.P., Baird, A.D. J. Urol. (2005) [Pubmed]
  2. Esmolol is more effective than sodium nitroprusside in reducing blood loss during orthognathic surgery. Blau, W.S., Kafer, E.R., Anderson, J.A. Anesth. Analg. (1992) [Pubmed]
  3. Dega osteotomy for the treatment of congenital dysplasia of the hip. Grudziak, J.S., Ward, W.T. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  4. Prophylaxis with indomethacin for heterotopic ossification after Chiari osteotomy of the pelvis. Randelli, G., Romanò, C.L. The Journal of bone and joint surgery. American volume. (1992) [Pubmed]
  5. A review of brain retraction and recommendations for minimizing intraoperative brain injury. Andrews, R.J., Bringas, J.R. Neurosurgery (1993) [Pubmed]
  6. Delayed osteotomy but not fracture healing in pediatric osteogenesis imperfecta patients receiving pamidronate. Munns, C.F., Rauch, F., Zeitlin, L., Fassier, F., Glorieux, F.H. J. Bone Miner. Res. (2004) [Pubmed]
  7. Recombinant human bone morphogenetic protein-2 enhances osteotomy healing in glucocorticoid-treated rabbits. Luppen, C.A., Blake, C.A., Ammirati, K.M., Stevens, M.L., Seeherman, H.J., Wozney, J.M., Bouxsein, M.L. J. Bone Miner. Res. (2002) [Pubmed]
  8. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. Sato, M., Ochi, T., Nakase, T., Hirota, S., Kitamura, Y., Nomura, S., Yasui, N. J. Bone Miner. Res. (1999) [Pubmed]
  9. Transtrochanteric anterior rotational osteotomy for idiopathic and steroid-induced necrosis of the femoral head. Indications and long-term results. Sugioka, Y., Hotokebuchi, T., Tsutsui, H. Clin. Orthop. Relat. Res. (1992) [Pubmed]
  10. Effect of local prostaglandin E2 on fracture callus in rabbits. Keller, J., Klamer, A., Bak, B., Suder, P. Acta orthopaedica Scandinavica. (1993) [Pubmed]
  11. A protocol for the management of failed alloplastic temporomandibular joint disc implants. Kearns, G.J., Perrott, D.H., Kaban, L.B. J. Oral Maxillofac. Surg. (1995) [Pubmed]
  12. Coronal patellar osteotomy: preliminary report of its use in chondromalacia patellae. Deliss, L. Proc. R. Soc. Med. (1977) [Pubmed]
  13. Correction of frontal bone hypertrophy with setback osteotomy and hydroxyapatite cement. Nahabedian, M.Y., Al-Shunnar, B., Manson, P.N. Annals of plastic surgery. (2000) [Pubmed]
  14. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. Bertone, A.L., Pittman, D.D., Bouxsein, M.L., Li, J., Clancy, B., Seeherman, H.J. J. Orthop. Res. (2004) [Pubmed]
  15. Effects of short-term treatment with corticosteroids and indomethacin on bone healing. A mechanical study of osteotomies in rats. Høgevold, H.E., Grøgaard, B., Reikerås, O. Acta orthopaedica Scandinavica. (1992) [Pubmed]
  16. Salter innominate osteotomy. The effect of blood supply to the roof of the acetabulum. Kasselt, M.R., Whiteside, L.A., Schoenecker, P.L., Simmons, D.J. Clin. Orthop. Relat. Res. (1984) [Pubmed]
  17. The effect of chevron osteotomy with lateral capsular release on the blood supply to the first metatarsal head. Jones, K.J., Feiwell, L.A., Freedman, E.L., Cracchiolo, A. The Journal of bone and joint surgery. American volume. (1995) [Pubmed]
  18. Total hip arthroplasty in diastrophic dysplasia. Helenius, I., Remes, V., Tallroth, K., Peltonen, J., Poussa, M., Paavilainen, T. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  19. A biomechanical analysis of fixation of intra-articular distal radial fractures with calcium-phosphate bone cement. Higgins, T.F., Dodds, S.D., Wolfe, S.W. The Journal of bone and joint surgery. American volume. (2002) [Pubmed]
  20. Fixation of distal femoral osteotomies with self-reinforced polymer/bioactive glass rods: an experimental study on rabbits. Pyhältö, T., Lapinsuo, M., Pätiälä, H., Pelto, M., Törmälä, P., Rokkanen, P. Biomaterials (2005) [Pubmed]
  21. Varus malalignment of the talar neck. Its effect on the position of the foot and on subtalar motion. Daniels, T.R., Smith, J.W., Ross, T.I. The Journal of bone and joint surgery. American volume. (1996) [Pubmed]
  22. Prevention of deep vein thrombosis after major knee surgery--a randomized, double-blind trial comparing a low molecular weight heparin fragment (enoxaparin) to placebo. Leclerc, J.R., Geerts, W.H., Desjardins, L., Jobin, F., Laroche, F., Delorme, F., Haviernick, S., Atkinson, S., Bourgouin, J. Thromb. Haemost. (1992) [Pubmed]
  23. Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Wildemann, B., Bamdad, P., Holmer, C.h., Haas, N.P., Raschke, M., Schmidmaier, G. Bone (2004) [Pubmed]
  24. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Zhang, W., Doherty, M., Arden, N., Bannwarth, B., Bijlsma, J., Gunther, K.P., Hauselmann, H.J., Herrero-Beaumont, G., Jordan, K., Kaklamanis, P., Leeb, B., Lequesne, M., Lohmander, S., Mazieres, B., Martin-Mola, E., Pavelka, K., Pendleton, A., Punzi, L., Swoboda, B., Varatojo, R., Verbruggen, G., Zimmermann-Gorska, I., Dougados, M. Ann. Rheum. Dis. (2005) [Pubmed]
  25. Opening wedge tibial osteotomy: the 3-triangle method to correct axial alignment and tibial slope. Noyes, F.R., Goebel, S.X., West, J. The American journal of sports medicine. (2005) [Pubmed]
  26. Medial opening-wedge high tibial osteotomy with use of porous hydroxyapatite to treat medial compartment osteoarthritis of the knee. Koshino, T., Murase, T., Saito, T. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  27. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. Geesink, R.G., Hoefnagels, N.H., Bulstra, S.K. The Journal of bone and joint surgery. British volume. (1999) [Pubmed]
  28. Growth factor stimulation of bone healing. Effects on osteoblasts, osteomies, and implants fixation. Lind, M. Acta orthopaedica Scandinavica. Supplementum. (1998) [Pubmed]
  29. New approach to cervical flexion deformity in ankylosing spondylitis. Case report. Duff, S.E., Grundy, P.L., Gill, S.S. J. Neurosurg. (2000) [Pubmed]
  30. Effects of locally applied vascular endothelial growth factor (VEGF) and VEGF-inhibitor to the rabbit tibia during distraction osteogenesis. Eckardt, H., Bundgaard, K.G., Christensen, K.S., Lind, M., Hansen, E.S., Hvid, I. J. Orthop. Res. (2003) [Pubmed]
  31. Free microvascular epiphyseal-plate transplantation. An experimental study in dogs. Nettelblad, H., Randolph, M.A., Weiland, A.J. The Journal of bone and joint surgery. American volume. (1984) [Pubmed]
  32. A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals. Connolly, C.K., Li, G., Bunn, J.R., Mushipe, M., Dickson, G.R., Marsh, D.R. J. Orthop. Res. (2003) [Pubmed]
  33. The anterior cruciate ligament and arthritis. Clatworthy, M., Amendola, A. Clinics in sports medicine. (1999) [Pubmed]
  34. Surgical approach to midline skull base tumors with olfactory preservation. Fukuta, K., Saito, K., Takahashi, M., Torii, S. Plast. Reconstr. Surg. (1997) [Pubmed]
  35. Combination of local and systemic parathyroid hormone enhances bone regeneration. Chen, H., Frankenburg, E.P., Goldstein, S.A., McCauley, L.K. Clin. Orthop. Relat. Res. (2003) [Pubmed]
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