Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Chromosomes, Artificial, Mammalian

Ohzeki, J. et al., Taylor, S.S. et al., Ikeno, M. et al., Hanish, J.P. et al., Vanderbyl, S.L. et al.

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High impact information on Chromosomes, Artificial, Mammalian

These four synthetic repetitive DNAs were introduced into cultured human cells (HT1080), and de novo centromere assembly was assessed using the mammalian artificial chromosome (MAC) formation assay [1].
To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC) containing human centromeric DNA [2].
The results suggest that telomere seeds interact with TRF and predict that mammalian artificial chromosomes will require wild-type telomeric repeats at, or near, their termini [3].
Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells [4].
Yeast artificial chromosomes (YACs) spanning the centromeric region of the human Y chromosome were introduced into mouse LA-9 cells by spheroplast fusion in order to determine whether they would form mammalian artificial chromosomes [5].

References

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA. Ohzeki, J., Nakano, M., Okada, T., Masumoto, H. J. Cell Biol. (2002) [Pubmed]
Construction of YAC-based mammalian artificial chromosomes. Ikeno, M., Grimes, B., Okazaki, T., Nakano, M., Saitoh, K., Hoshino, H., McGill, N.I., Cooke, H., Masumoto, H. Nat. Biotechnol. (1998) [Pubmed]
Stringent sequence requirements for the formation of human telomeres. Hanish, J.P., Yanowitz, J.L., de Lange, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells. Vanderbyl, S.L., Sullenbarger, B., White, N., Perez, C.F., MacDonald, G.N., Stodola, T., Bunnell, B.A., Ledebur, H.C., Lasky, L.C. Exp. Hematol. (2005) [Pubmed]
Analysis of extrachromosomal structures containing human centromeric alphoid satellite DNA sequences in mouse cells. Taylor, S.S., Larin, Z., Tyler-Smith, C. Chromosoma (1996) [Pubmed]

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