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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Protein Interaction Mapping

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High impact information on Protein Interaction Mapping

  • Our fly Protein Interaction Map (PIM) is surprisingly different from the one recently proposed by Giot et al. with little overlap between the two data sets [1].
  • Our previous work highlighted the selection of phage-peptides that bind to specific isoforms of MDM2 protein and in this work we subjected the putative MDM2-binding proteins to phage-peptide display to expand further on putative protein interaction maps [2].
  • A protein-protein interaction map for H. pylori constructed from a high-throughput screen of a yeast two-hybrid assay ( revealed interactions between sigma(54) and the conserved hypothetical protein HP0958 [3].
  • The protein-protein interaction map of H. pylori, which is based on a high-throughput two-hybrid screen (Rain et al., 2001. Nature 409, 211-215) indicated a protein-protein interaction between the gene product of ORF hp137 and both the histidine kinase HP244 and the flagellar hook protein HP908 [4].
  • We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput technology, to map protein-protein interaction networks systematically in mammalian cells and applied it to the transforming growth factor-beta (TGFbeta) pathway [5].

Associations of Protein Interaction Mapping with chemical compounds


Gene context of Protein Interaction Mapping


  1. Protein interaction mapping: a Drosophila case study. Formstecher, E., Aresta, S., Collura, V., Hamburger, A., Meil, A., Trehin, A., Reverdy, C., Betin, V., Maire, S., Brun, C., Jacq, B., Arpin, M., Bellaiche, Y., Bellusci, S., Benaroch, P., Bornens, M., Chanet, R., Chavrier, P., Delattre, O., Doye, V., Fehon, R., Faye, G., Galli, T., Girault, J.A., Goud, B., de Gunzburg, J., Johannes, L., Junier, M.P., Mirouse, V., Mukherjee, A., Papadopoulo, D., Perez, F., Plessis, A., Rossé, C., Saule, S., Stoppa-Lyonnet, D., Vincent, A., White, M., Legrain, P., Wojcik, J., Camonis, J., Daviet, L. Genome Res. (2005) [Pubmed]
  2. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. Burch, L.R., Scott, M., Pohler, E., Meek, D., Hupp, T. J. Mol. Biol. (2004) [Pubmed]
  3. Stable accumulation of sigma54 in Helicobacter pylori requires the novel protein HP0958. Pereira, L., Hoover, T.R. J. Bacteriol. (2005) [Pubmed]
  4. Protein-protein interaction of HP137 with histidine kinase HP244 does not contribute to flagellar regulation in Helicobacter pylori. Jiménez-Pearson, M.A., Dietz, P., Beier, D. Microbiol. Res. (2005) [Pubmed]
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles, M., Brown, K.R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R.S., Shinjo, F., Liu, Y., Dembowy, J., Taylor, I.W., Luga, V., Przulj, N., Robinson, M., Suzuki, H., Hayashizaki, Y., Jurisica, I., Wrana, J.L. Science (2005) [Pubmed]
  6. A high resolution protein interaction map of the yeast Mediator complex. Guglielmi, B., van Berkum, N.L., Klapholz, B., Bijma, T., Boube, M., Boschiero, C., Bourbon, H.M., Holstege, F.C., Werner, M. Nucleic Acids Res. (2004) [Pubmed]
  7. Visualisation and graph-theoretic analysis of a large-scale protein structural interactome. Bolser, D., Dafas, P., Harrington, R., Park, J., Schroeder, M. BMC Bioinformatics (2003) [Pubmed]
  8. Development of a high-throughput yeast two-hybrid screening system to study protein-protein interactions in plants. Fang, Y., Macool, D.J., Xue, Z., Heppard, E.P., Hainey, C.F., Tingey, S.V., Miao, G.H. Mol. Genet. Genomics (2002) [Pubmed]
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